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Table 3 Diagnostic performance of biomarkers.

From: Sepsis biomarkers in unselected patients on admission to intensive or high-dependency care

Marker AUC (95% CI) Cut off Sensitivity Specificity PPV NPV
PCT 0.84 (0.78 to 0.90) 1.0 ng/ml 71% 82% 83% 71%
PSP 0.93 (0.89 to 0.97) 30 ng/ml 90% 83% 86% 87%
sCD25 0.90 (0.85 to 0.95) 2.5 ng/ml 83% 83% 85% 81%
HBP 0.60 (0.52 to 0.69) 50 ng/ml 78% 36% 59% 59%
IL6 0.81 (0.74 to 0.87) 200 pg/ml 68% 68% 71% 65%
IL8 0.78 (0.71 to 0.85) 80 pg/ml 78% 63% 71% 71%
IL1β 0.76 (0.69 to 0.84) 1.0 pg/ml 61% 88% 86% 69%
  1. Biomarker performance is shown for 162 patients in distinguishing sepsis (n = 87) from SIRS without an infective aetiology (n = 75) Data for GMCSF and TNFα are not shown as only a minority of patients had detectable levels of these markers.