| HES 130/0.42 (n= 98) | Ringer's acetate (n= 92) |
---|---|---|
Time to follow-up - months | 13 (9-17) | 14 (10-18) |
Age - years | 66 (59-74) | 66 (58-75) |
Male gender - no. (%) | 52 (53) | 53 (58) |
Included at university hospital - no. (%) | 35 (36) | 36 (39) |
Surgery 1 - no. (%) | Â | Â |
   Emergency | 31 (32) | 33 (36) |
   Elective | 7 (7) | 17 (18) |
Source of ICU admittance - no. (%) | Â | Â |
   Emergency department | 32 (33) | 21 (23) |
   General ward | 40 (41) | 39 (42) |
   Operating or recovery room | 17 (17) | 21 (23) |
   Other ICU in the same hospital | 2 (2) | 2 (2) |
   Other hospital | 7 (7) | 9 (10) |
Source of sepsis 2 - no. (%) | Â | Â |
   Lungs | 42 (43) | 38 (41) |
   Abdomen | 40 (41) | 33 (36) |
   Urinary tract | 13 (13) | 13 (14) |
   Soft tissue | 9 (9) | 14 (15) |
   Other | 10 (10) | 12 (13) |
Positive culture from blood or a sterile site - no. (%) | 17 (17) | 11 (12) |
Time from ICU admission to randomization - hours | 3 (1-11) | 3 (1-14) |
SAPS II | 48 (36-58) | 50 (38-59) |
SOFA score 3 | 7 (5-9) | 7 (5-9) |
Shock 4 - no. (%) | 80 (82) | 80 (87) |
Acute kidney injury 5 - no. (%) | 36 (37) | 35 (38) |
Mechanical ventilation - no. (%) | 44 (45) | 54 (59) |
Comorbidities | Â | Â |
   Diabetes mellitus - no. (%) | 12 (12) | 16 (17) |
   Arterial hypertension - no. (%) | 42 (43) | 39 (42) |
   Chronic renal disease6 - no. (%) | 9 (10) | 14 (17) |
   Hematological malignancy - no. (%) | 6 (6) | 9 (10) |
Previous admission for - no. (%) | Â | Â |
   Heart failure or myocardial infarction | 10 (10) | 12 (13) |
   Stroke | 7 (7) | 6 (7) |
   Asthma or COPD | 12 (12) | 12 (13) |
Any ventilation in the ICU, n (%) | 71 (72) | 72 (78) |
Days in ventilator if treated, median (IQR) | 6 (3-14) | 5 (3-12) |
Any renal replacement therapy dialysis in the ICU, n (%) | 18 (18) | 15 (16) |
Days in renal replacement therapy if treated, median (IQR) | 7 (3-22) | 10 (6-22) |
Days in ICU, median (IQR) | 6 (3-14) | 8 (4-14) |
Days in hospital in the 90 days follow-up period, median (IQR) | 32 (20-50) | 30 (20-53) |