Plasma urea and creatinine sampled 4 hours after laparotomy and endotoxemia ( n = 8 all groups), experiment 1. Smaller increases were observed in pooled dopexamine groups compared with controls (P < 0.005). Data presented as mean (SEM) when all groups were normally distributed; otherwise, median (IQR) when more than one group were not normally distributed. Urea, one-way ANOVA (Bonferroni posttests, **P < 0.01, ***P < 0.001 compared with controls). Creatinine: Kruskal-Wallis test (post hoc unpaired t tests (sham and D1), **P < 0.01 compared with controls; post hoc Mann-Whitney test (D2), *P < 0.05 compared with controls).