Plasma lactate ( n = 8 for all groups) and base deficit ( n = 8 all except D0.5 and D1 ( n = 6 each)) at 4 hours after laparotomy and endotoxemia, experiment 1. In control animals, lactate significantly increased compared with shams, whereas this was not observed in dopexamine-treated animals (P < 0.001 pooled dopexamine versus control). A similar observation was made for base deficit (P < 0.05 pooled dopexamine versus control). Data presented as mean (SEM). One-way ANOVA (Bonferroni posttests, *P < 0.05, **P < 0.01, ***P < 0.001 compared with controls).