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Table 3 Studies reporting pediatric and adult patients received rFVIIa while receiving ECMO

From: Recombinant factor VIIa for uncontrollable bleeding in patients with extracorporeal membrane oxygenation: report on 15 cases and literature review

Study Number Age, median (IQR) rFVIIa dose
(μg/kg)
rFVIIa doses received, number Effect on blood-product requirements or bleeding Thrombotic events Deaths, number
Pediatric patients
Wittenstein et al. [30] 4 0.625 (0.25-9) months 90-120 2 ↓81.9% PRC between before and after one rFVIIa infusion
↓90% FFP between before and after one rFVIIa infusion
0 0
Velik-Salchner et al. [29] 1 0.5 months 90 1 Bleeding stopped 1 (arterial) 1
Dominguez et al. [24] 2 11 and 13 years 90 3 and 10 ↓88.7% total blood products between 12 hours before and after rFVIIa infusion for case 1
↓46.7% total blood products between 24 hours before and after rFVIIa infusion for case 2
0 1
Veldman et al. [16] 7 4 (0.4-14.5) months 83 (61-106) 3 (2-3.5) ↓23.1% PRC between before and after one rFVIIa infusion
↓35.3% FFP between before and after one rFVIIa infusion
0 3
Argawal et al. [22] 11a 9.5 days 36.5 ± 18.2 1.6 ± 7 ↓42% PRC between before and after one rFVIIa infusion (P < 0.05)
↓59.3% FFP between before and after one rFVIIa infusion (P < .05)
2 circuit thromboses 3
Chalwin et al. [23] 1 18 months 90 1 Bleeding stopped 1 circuit thrombosis 1
Guzzeta et al. [26] 1 5 days 70 2 ↓66.7% PRC after the two rFVIIa doses
↓100% FFP after two rFVIIa doses
1 extensive distal thrombotic emboli 1
Schneider et al. [28] 4b 6.7 (1-11.2) years 180 (146.25-180) 2 (1.75-2) ↓46.5% (-71.25 to -2.25) PRC between 12 hours before and after rFVIIa infusion
14.5% (-49.5 to 21.5) FFP between 24 hours before and after rFVIIa infusion
1 stroke 2
Niebler et al. [27] 17 0.1 (0-14) years 45-90 1.5 (1-2) ↓50% total blood products between before and after rFVIIa infusion
(P = 0.05)
4 clinical thromboses
2 oxygenator failures
2 circuit obstructions
12
Adult patients
Bui et al. [17] 1 56 years 146.5 2 ↓53.8% PRC between the 12 hours before and after rFVIIa infusion
↓16.7% FFP between 12 hours before and after rFVIIa infusion
1 circuit thrombosis 1
Brose et al. [15] 1 17 years 220 2 Bleeding stopped (↓90% bleeding after rFVIIa infusion) 0 0
Schneider et al. [28] 5b 48 (45.2-52) years 90 (54-105) 2 (1-2) ↓61% (-79 to -47) PRC between the 12 hours before and after rFVIIa infusion
↓33% (-58 to 42) FFP between the 24 hours before and after injection of rFVIIa
0 3
Syburra et al. [35] 1 58 years 84.7 1 Bleeding stopped 1 left atrium thrombosis 1
Dunne et al. [25] 1 63 years 47 1 Bleeding stopped (↓90% bleeding after rFVIIa infusion) 0 0
  1. FFP, fresh-frozen plasma; PRC, packed red cells; rFVIIa, recombinant activated factor VII. aAnalysis concerns 11 of the 12 patients on ECMO who received rFVIIa; one patient did not respond to rFVIIa. bThe authors reported on 12 patients, among whom four were infants with ECMO, five were adults with ECMO, and three were adults with ventricle-assist devices.