Table 3 Studies reporting pediatric and adult patients received rFVIIa while receiving ECMO

Wittenstein et al. [30]

4

0.625 (0.25-9) months

90-120

2

↓81.9% PRC between before and after one rFVIIa infusion

↓90% FFP between before and after one rFVIIa infusion

0

0

Velik-Salchner et al. [29]

1

0.5 months

90

1

Bleeding stopped

1 (arterial)

1

Dominguez et al. [24]

2

11 and 13 years

90

3 and 10

↓88.7% total blood products between 12 hours before and after rFVIIa infusion for case 1

↓46.7% total blood products between 24 hours before and after rFVIIa infusion for case 2

0

1

Veldman et al. [16]

7

4 (0.4-14.5) months

83 (61-106)

3 (2-3.5)

↓23.1% PRC between before and after one rFVIIa infusion

↓35.3% FFP between before and after one rFVIIa infusion

0

3

Argawal et al. [22]

11^a

9.5 days

36.5 ± 18.2

1.6 ± 7

↓42% PRC between before and after one rFVIIa infusion (P < 0.05)

↓59.3% FFP between before and after one rFVIIa infusion (P < .05)

2 circuit thromboses

3

Chalwin et al. [23]

1

18 months

90

1

Bleeding stopped

1 circuit thrombosis

1

Guzzeta et al. [26]

1

5 days

70

2

↓66.7% PRC after the two rFVIIa doses

↓100% FFP after two rFVIIa doses

1 extensive distal thrombotic emboli

1

Schneider et al. [28]

4^b

6.7 (1-11.2) years

180 (146.25-180)

2 (1.75-2)

↓46.5% (-71.25 to -2.25) PRC between 12 hours before and after rFVIIa infusion

14.5% (-49.5 to 21.5) FFP between 24 hours before and after rFVIIa infusion

1 stroke

2

Niebler et al. [27]

17

0.1 (0-14) years

45-90

1.5 (1-2)

↓50% total blood products between before and after rFVIIa infusion

(P = 0.05)

4 clinical thromboses

2 oxygenator failures

2 circuit obstructions

12

Bui et al. [17]

1

56 years

146.5

2

↓53.8% PRC between the 12 hours before and after rFVIIa infusion

↓16.7% FFP between 12 hours before and after rFVIIa infusion

1 circuit thrombosis

1

Brose et al. [15]

1

17 years

220

2

Bleeding stopped (↓90% bleeding after rFVIIa infusion)

0

0

Schneider et al. [28]

5^b

48 (45.2-52) years

90 (54-105)

2 (1-2)

↓61% (-79 to -47) PRC between the 12 hours before and after rFVIIa infusion

↓33% (-58 to 42) FFP between the 24 hours before and after injection of rFVIIa

0

3

Syburra et al. [35]

1

58 years

84.7

1

Bleeding stopped

1 left atrium thrombosis

1

Dunne et al. [25]

1

63 years

47

1

Bleeding stopped (↓90% bleeding after rFVIIa infusion)

0

0