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Table 5 Logistic regression analysis with ICU mortality as the dependent variable inpatients with severe sepsis

From: The influence of gender on the epidemiology of and outcome from severe sepsis

  Univariate Multivariatea
  OR (95% CI) P value OR (95% CI) P value
Age (per year) 1.03 (1.02 to 1.05) < 0.001 1.03 (1 to 1.059) 0.016
Sex (female) 2.01 (1.20 to 3.37) 0.008 2.23 (1.17 to 4.24) 0.014
Comorbidities     
   Diabetes mellitus 0.79 (0.43 to 1.45) 0.465   
   Renal failure (with dialysis) 0.21 (0.07 to 0.64) 0.006 2.9 (0.68 to 12.45) 0.151
   Renal failure (without dialysis) 1.05 (0.52 to 2.15) 0.887   
   Heart failure (NYHA III to IV) 0.96 (0.42 to 2.19) 0.929   
   COPD 0.50 (0.19 to 1.28) 0.147 1.75 80.58 to 5.32) 0.319
SAPS II (per point) 1.04 (1.03 to 1.06) < 0.001 1.03 (1.01 to 1.05) 0.002
Type of admission     
   Elective surgery R NA R NA
   Emergency surgery 1.56 (0.64 to 3.84) 0.330 1.09 (0.38 to 3.5) 0.891
   Medical admission 2.28 (0.95 to 5.43) 0.064 1.7 (0.5 to 5.76) 0.392
Initial SOFA subscores     
   SOFA respiratory 1.53 (1.21 to 1.92) < 0.001 1.65 (1.24 to 2.2) 0.001
   SOFA hepatologic 1.18 (0.96 to 1.45) 0.110 1.25 (0.94 to 1.66) 0.126
   SOFA hematologic 1.32 (1.08 to 1.60) 0.006 1.28 (0.99 to 1.65) 0.059
   SOFA renal 1.29 (1.07 to 1.54) 0.006 0.92 (0.71 to 1.19) 0.535
   SOFA neurologic 1.097 (0.94 to 1.29) 0.257   
   SOFA cardiovascular 1.272 (1.09 to 1.49) 0.003 1.24 (1.02 to 1.51) 0.034
Referring facility     
   Other hospital R NA R NA
   Surgical ward 0.2 (0.09 to 0.45) < 0.001 5.17 (1.2 to 22.29) 0.027
   Emergency department 0.93 (0.28 to 3.1) 0.913 3.53 (1.52 to 8.21) 0.003
   Medical ward 0.52 (0.26 to 1.05) 0.068 1.43 (0.52 to 3.93) 0.492
   Other ICU 0.31 (0.15 to 0.63) 0.001 4.87 (1.85 to 12.85) 0.001
Source of infection     
   Pulmonary 0.926 (0.586 to 1.465) 0.743   
   Abdominal 0.542 (0.338 to 0.871) 0.011 2.51 (1.15 to 5.44) 0.02
   Renal 1.697 (0.640 to 4.501) 0.288   
   Central nervous system 0.833 (0.219 to 3.164) 0.789   
   Bone 3.185 (0.328 to 30.965) 0.318   
   Soft tissue 1.208 (0.427 to 3.417) 0.722   
  1. Logistic regression analysis with ICU mortality as the dependent variable inpatients with severe sepsis (n = 305). CI, confidence interval; COPD,chronic obstructive pulmonary disease; NA, not applicable; NYHA, New York HeartAssociation classification; OR, odds ratio; R, reference category; SAPS,Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment.aHosmer and Lemeshow χ2 = 10.543 (P =0.229). Nagelkerke pseudo-R2 = 0.39.