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Table 4 Receiver operating characteristic (ROC) curve and in-sample reclassification analysis of the addition of each or the combination of IL-6 and hFABP (natural log-transformed) to the baseline clinical model for stroke outcome

From: Predictive value of circulating interleukin-6 and heart-type fatty acid binding protein for three months clinical outcome in acute cerebral infarction: multiple blood markers profiling study

  Discrimination Reclassification
  AUC (95% CI) P b NRI P c IDI P d
Baseline clinical modela 0.910 (0.858 to 0.948) - - -   
   + log IL-6 0.931 (0.883 to 0.964) 0.075 0.09 0.036 0.03 0.024
   + log hFABP 0.926 (0.877 to 0.960) 0.110 0.07 0.232 0.02 0.032
   + log IL-6 + log hFABP 0.939 (0.893 to 0.970) 0.032 0.18 0.005 0.06 0.001
  1. aModel with age and initial NIHSS score; bP-value for AUC using DeLong method with the baseline clinical model as a reference; cP-value for net classification improvement with the baseline clinical model as a reference; dP-value for integrated discrimination improvement with the baseline clinical model as a reference. AUC, area under curve; IDI, integrated discrimination improvement; log, natural log-transformed value; NRI, net reclassification improvement.