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Table 2 Comparison of median concentrations of blood markers between favorable and poor outcome groups

From: Predictive value of circulating interleukin-6 and heart-type fatty acid binding protein for three months clinical outcome in acute cerebral infarction: multiple blood markers profiling study

 

All

(number = 175)

Favorable

(number = 111)

Poor

(number = 64)

P a

Neuronal

    

   NSE (ng/ml)

6.5 (1.9 to 10.8)

5.6 (1.6 to 10.3)

7.7 (3.0 to 11.5)

0.14

   Ngb (ng/ml)

0.0 (0.0 to 2.7)

0.0 (0.0 to 0.9)

0.3 (0.0 to 9.7)

< 0.001

   hFABP (ng/ml)

10.0 (6.2 to 16.3)

8.4 (5.5 to 11.9)

16.3 (9.9 to 29.7)

< 0.001

   VSNL-1 (%)b

12 (6.9)

7 (6.3)

5 (7.8)

0.95

Astroglial

    

   S100B (pg/ml)

31.9 (0.0 - 124.9)

20.0 (0 to 60.3)

135.2 (40.0 to 344.6)

< 0.001

   GFAP (%)b

50 (28.6)

23 (20.7)

27 (42.2)

0.004

Inflammatory

    

   IL-6 (pg/ml)

4.6 (0.9 to 13.0)

2.2 (0.6 to 5.5)

12.1 (6.7 to 48.0)

< 0.001

   MMP-9 (ng/ml)

65.4 (30.9 to 124.1)

45.7 (21.9 to 79.5)

120.5 (61.8 to 228.3)

< 0.001

   TNF-α (pg/ml)

2.3 (0.0 to 8.9)

1.3 (0.0 to 8.0)

3.3 (0.0 to 10.4)

0.22

   CRP (mg/dl)

0.26 (0.09 to 0.94)

0.19 (0.06 to 0.36)

0.87 (0.18 to 4.40)

< 0.001

Haemostatic

    

   PAI-1 (ng/ml)

11.1 (4.5 to 21.8)

10.3 (4.2 to 23.1)

11.5 (5.9 to 20.9)

0.57

   D-dimer (ng/ml)

521 (368 to 1083)

466 (355 to 933)

938 (450 to 1629)

0.001

  1. aStatistical analysis conducted by the Mann-Whitney U test; bCategorical variables. Values in round brackets indicate interquartile range. CRP, C-reactive protein; GFAP, glial fibrillary acidic protein; hFABP, heart type fatty acid binding protein; MMP-9 matrix metalloproteinase-9; Ngb, neuroglobin; NSE, neuron-specific enolase; PAI-1, plasminogen activator inhibitor-1; VSNL-1, visinin-like protein 1.