Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response

Wang, Wei; Zhao, Feng; Fang, Yong; Li, Xiantao; Shen, Lei; Cao, Tongwa; Zhu, Hechen

doi:10.1186/cc12558

Critical Care

Table 2 Blood cell count, chemistry and organ functions.

From: Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response

	Baseline	6 hours	12 hours	18 hours	24 hours
WBC (×10⁹/L)
Sham	11.8 ± 2.1	11.6 ± 1.4	13.1 ± 1.4	15.0 ± 2.4	15.1 ± 1.5
Con^a	9.3 ± 0.4	3.2 ± 0.5	3.8 ± 0.5	17.2 ± 0.3	22.0 ± 3.9
EP^ab	9.7 ± 1.9	3.3 ± 0.9	3.2 ± 0.6	11.3 ± 1.8	13.3 ± 2.7
GL^ab	9.5 ± 3.7	3.4 ± 1.3	4.3 ± 0.8	9.0 ± 1.8	13.5 ± 5.9
Plt (×10¹²/L)
Sham	278.7 ± 10.4	291.7 ± 14.6	292.7 ± 11.0	276.3 ± 11.1	273.7 ± 17.6
Con^a	274.7 ± 39.8	158.7 ± 21.3	64.0 ± 3.1	57.3 ± 9.0	53.7 ± 9.1
EP^ab	316.7 ± 48.8	139.0 ± 14.2	68.0 ± 9.1	169.3 ± 40.4	185.0 ± 7.6
GL^ab	343.3 ± 45.2	165.0 ± 20.1	85.0 ± 18.5	184.3 ± 15.8	172.0 ± 16.3
Alt (mmol/L)
Sham	52.7 ± 6.4	55.3 ± 4.5	55.3 ± 8.4	55.7 ± 3.2	57.7 ± 5.0
Con^a	59.3 ± 4.8	71.0 ± 8.3	69.0 ± 7.0	75.7 ± 12.5	75.0 ± 8.9
EP^a	56.3 ± 5.9	68.0 ± 5.7	72.0 ± 8.0	73.3 ± 8.1	74.3 ± 7.6
GL^ab	59.0 ± 5.5	71.3 ± 5.4	72.8 ± 5.6	57.7 ± 4.1	56.0 ± 6.4
Cr (mmol/L)
Sham	71.3 ± 8.4	77.0 ± 9.6	79.7 ± 9.0	83.0 ± 6.6	88.3 ± 5.8
Con^a	70.0 ± 3.9	83.7 ± 6.9	119.7 ± 6.7	181.3 ± 14.5	211.0 ± 21.7
EP^ab	77.7 ± 6.6	81.0 ± 4.6	109.3 ± 5.1	146.0 ± 33.1	180.7 ± 11.9
GL^ab	74.7 ± 12.1	82.0 ± 23.3	111.7 ± 27.9	116.7 ± 21.2	143.7 ± 15.9
PT (seconds)
Sham	11.2 ± 1.2	12.0 ± 1.9	12.0 ± 1.6	11.9 ± 1.9	12.4 ± 2.4
Con^a	11.2 ± 1.6	12.1 ± 1.6	14.8 ± 2.3	14.9 ± 1.7	14.4 ± 2.2
EP^a	10.4 ± 0.5	12.1 ± 1.3	14.3 ± 1.9	15.4 ± 1.3	15.1 ± 1.5
GL^a	10.9 ± 0.8	12.6 ± 1.3	14.4 ± 0.7	14.8 ± 1.2	14.9 ± 1.3
Na (mmol/L)
Sham	140.7 ± 1.2	141.3 ± 1.5	143.7 ± 2.3	144.0 ± 1.0	144.7 ± 1.2
Con^a	140.7 ± 3.6	141.7 ± 1.4	140.7 ± 2.3	139.3 ± 2.9	140.7 ± 2.3
EP	144.0 ± 0.9	143.0 ± 0.9	144.0 ± 0.9	139.3 ± 5.7	143.0 ± 2.7
GL^b	145.3 ± 2.3	145.7 ± 2.9	143.0 ± 0.9	143.3 ± 3.6	143.7 ± 3.6

^aP < 0.05 versus sham group by repeated measures ANOVA; ^bP < 0.05 versus Con group by repeated measures ANOVA; Data are mean ± SD. Alt, alanine aminotransferase; ANOVA, analysis of variance; Con, control; Cr, creatinine; EP, ethyl pyruvate; GL, glycyrrhizin; Plt, platelet; PT, prothrombin time; WBC, white blood cell.

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