Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response

Wang, Wei; Zhao, Feng; Fang, Yong; Li, Xiantao; Shen, Lei; Cao, Tongwa; Zhu, Hechen

doi:10.1186/cc12558

Critical Care

Table 1 Systemic and pulmonary hemodynamics, oxygen exchange and metabolic data.

From: Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response

	Baseline	6 hours	12 hours	18 hours	24 hours
pH
Sham	7.47 ± 0.01	7.47 ± 0.01	7.47 ± 0.01	7.46 ± 0.04	7.46 ± 0.02
Con	7.47 ± 0.01	7.42 ± 0.02	7.41 ± 0.03	7.41 ± 0.03	7.44 ± 0.03
EP	7.48 ± 0.03	7.46 ± 0.03	7.39 ± 0.03	7.38 ± 0.02	7.40 ± 0.04
GL^ab	7.57 ± 0.02	7.41 ± 0.09	7.51 ± 0.14	7.40 ± 0.05	7.38 ± 0.07
PaCO₂ (mmHg)
Sham	38.8 ± 1.9	38.3 ± 3.2	39.3 ± 2.8	40.2 ± 2.8	39.0 ± 3.2
Con	40.9 ± 1.8	43.9 ± 2.7	42.6 ± 2.3	42.9 ± 2.6	41.9 ± 2.6
EP	37.2 ± 3.0	37.9 ± 4.8	36.5 ± 1.8	36.4 ± 2.5	36.3 ± 2.0
GL	36.1 ± 2.0	36.5 ± 11.9	35.6 ± 10.7	43.2 ± 5.4	40.8 ± 5.9
PaO₂ (mmHg)
Sham	251.7 ± 16.3	234.7 ± 19.4	231.3 ± 32.3	240.3 ± 17.6	230.0 ± 19.5
Con^a	255.3 ± 13.9	168.3 ± 16.9	170.0 ± 19.5	181.0 ± 14.6	189.3 ± 23.3
EP^ab	254.3 ± 12.2	164.3 ± 17.4	175.7 ± 14.2	223.7 ± 20.0	221.0 ± 34.1
GL^ab	257.7 ± 13.4	161.3 ± 22.3	172.7 ± 13.9	231.3 ± 22.2	229.0 ± 24.8
HCO₃ (mmHg)
Sham	29.5 ± 2.7	28.3 ± 1.8	29.1 ± 2.2	30.2 ± 3.0	29.0 ± 2.5
Con	32.1 ± 3.1	30.6 ± 1.7	30.1 ± 1.3	29.0 ± 1.5	30.2 ± 1.8
EP^ab	29.8 ± 3.4	27.0 ± 1.4	23.8 ± 1.1	23.4 ± 1.4	23.9 ± 1.6
GL	33.3 ± 2.1	33.0 ± 6.7	29.3 ± 5.6	30.3 ± 5.1	33.5 ± 4.5
BE (mmol/L)
Sham	3.7 ± 1.5	2.7 ± 1.2	3.3 ± 2.1	1.7 ± 0.6	1.7 ± 1.5
Con^a	4.0 ± 3.1	0.3 ± 2.7	-2.7 ± 2.1	-2.0 ± 1.5	-3.3 ± 2.3
EP^ab	4.3 ± 1	1.0 ± 0.9	-2.7 ± 1.0	-1.0 ± 0.9	1.0 ± 0.6
GL^ab	4.0 ± 1.3	0.3 ± 0.8	-1.7 ± 1.4	-0.3 ± 1.4	1.5 ± 0.5
Lactate (mmol/L)
Sham	0.8 ± 0.4	0.9 ± 0.4	1.0 ± 0.5	0.9 ± 0.4	1.0 ± 0.5
Con^a	0.9 ± 0.4	1.9 ± 0.6	2.6 ± 0.8	2.4 ± 0.1	2.3 ± 0.2
EP^ab	1.3 ± 0.4	2.1 ± 0.6	2.7 ± 0.8	1.3 ± 0.4	1.1 ± 0.3
GL^ab	1.2 ± 0.6	2.5 ± 1.0	3.3 ± 1.4	1.4 ± 0.9	1.0 ± 0.5
HR (beats/min)
Sham	126.7 ± 7.0	123.0 ± 16.6	121.0 ± 11.5	123.0 ± 7.9	129.3 ± 4.0
Con^a	135.0 ± 13.4	89.3 ± 8.5	90.0 ± 7.2	97.7 ± 7.2	102.3 ± 8.7
EP^a	125.0 ± 11.8	88.3 ± 14.9	88.0 ± 6.3	100.3 ± 4.9	109.0 ± 4.5
GL^a	123.0 ± 10.1	87.7 ± 8.3	92.7 ± 9.6	102.3 ± 7.2	114.7 ± 9.0
MAP (mmHg)
Sham	94.3 ± 8.02	95.3 ± 4.7	87.7 ± 8.5	85.7 ± 6.0	82.7 ± 6.8
Con^a	89.3 ± 7.2	67.7 ± 12	64.3 ± 7.6	65.7 ± 9.6	67.0 ± 12.6
EP^ab	82.7 ± 8.3	65.7 ± 11.5	63.7 ± 7.4	72.7 ± 9.6	84.3 ± 9.3
GL^ab	84.3 ± 11.5	63.7 ± 5.1	60.0 ± 5.6	76.3 ± 5.8	85.7 ± 4.6
MPAP (mmHg)
Sham	20.7 ± 4.7	22.7 ± 7.2	26.3 ± 6.8	25.3 ± 5.0	26.3 ± 6.4
Con	19.3 ± 1.4	39.3 ± 7.6	37.3 ± 4.4	38.7 ± 2.7	38.0 ± 2.4
EP	19.7 ± 4.6	37.7 ± 3.6	37.7 ± 2.7	33.0 ± 2.4	30.7 ± 2.1
GL	20.3 ± 4.6	37.0 ± 3.2	38.7 ± 2.6	36.7 ± 1.0	31.3 ± 4.4
CVP (mmHg)
Sham	11.0 ± 2.0	10.3 ± 0.6	12.3 ± 3.8	15.3 ± 2.5	12.3 ± 2.3
Con	11.7 ± 2.1	11.3 ± 0.5	13.3 ± 2.6	11.7 ± 3.7	10.3 ± 1.9
EP	9.0 ± 2.4	9.3 ± 4.2	11.3 ± 4.5	11.0 ± 5.0	12.3 ± 3.4
GL	13.3 ± 2.3	14.0 ± 4.7	12.7 ± 4.6	13.0 ± 3.9	13.7 ± 2.9
PAWP (mmHg)
Sham	8.0 ± 1.7	7.3 ± 1.5	6.7 ± 1.2	7.3 ± 0.6	7.3 ± 1.5
Con	7.0 ± 1.8	7.3 ± 2.6	8.3 ± 3.4	8.0 ± 3.2	7.0 ± 0.9
EP	8.7 ± 3.1	8.0 ± 2.4	7.0 ± 0.9	9.3 ± 1.4	7.3 ± 1.4
GL	7.7 ± 1.4	6.7 ± 1.9	6.0 ± 0.9	6.3 ± 1.9	7.7 ± 1.4
Urine (ml/kg/h)
Sham	0	5.0 ± 0.5	6.4 ± 1.1	6.1 ± 1.0	5.1 ± 1.0
Con	0	6.4 ± 1	6.0 ± 1.8	6.0 ± 1.5	5.5 ± 0.8
EP^ab	0	6.1 ± 0.9	7.5 ± 1.1	7.7 ± 1.0	8.5 ± 1.1
GL^ab	0	5.1 ± 0.8	6.7 ± 0.8	7.4 ± 1.0	8.0 ± 0.6

^aP < 0.05 versus sham group by repeated measures ANOVA; ^bP < 0.05 versus Con group by repeated measures ANOVA. Data are mean ± SD. ANOVA, analysis of variance; BE, base excess; Con, control; CVP, central venous pressure; EP, ethyl pyruvate; GL, glycyrrhizin; HR, heart rate; MAP, mean arterial pressure; MPAP, mean pulmonary artery pressure; PAWP, pulmonary artery wedge pressure.

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