Table 3 Summary of pooled results

Hospital mortality

3

(431)

Intervention: 76/223 (34%)

RR, 0.72 (CI, 0.58 to 0.91); P = 0.005; I² = 0

132 fewer per 1,000 (from 42 fewer to 198 fewer)

Moderate^c

Control: 98/208 (47%)

ICU mortality

3

(431)

Intervention: 70/223 (31.4%)

RR, 0.70 (CI, 0.55 to 0.89); P = 0.004; I² = 0

134 fewer per 1,000 (from 49 fewer to 201 fewer)

Moderate^c

Control: 93/208 (44.7%)

Mortality at 28 days

3

(431)

Intervention: 57/223 (25.6%)

RR, 0.66 (CI, 0.50 to 0.87); P = 0.003; I² = 0

132 fewer per 1,000 (from 51 fewer to 195 fewer)

Moderate^c

Control: 81/208 (39%)

Days free of mechanical ventilation at 28 days

3

(431)

n/a

MD, 1.91 (CI, 0.28 to 3.55); P = 0.02; I² = 0

n/a

Moderate^c

Duration of mechanical ventilation

3

(431)

n/a

MD, 1.21 (CI, 4.23 to 1.81); P = 0.43; I² = 0

n/a

Moderate^c

Barotrauma

3

(431)

Intervention: 9/223 (4%)

RR, 0.43 (CI, 0.20 to 0.90); P = 0.02; I² = 0

55 fewer per 1,000 (from 10 fewer to 77 fewer)

Moderate^c

Control: 20/208 (9.6%)

ICU Acquired weakness

3

(431)

Intervention: 73/223 (32.7%)

RR, 1.08 (CI, 0.83 to 1.41); P = 0.57; I² = 0

24 more per 1,000 (from 51 fewer to 122 more)

Very weak^cde

Control: 62/208 (30%)

ICU Length of stay

1

(339)

n/a

MD, 1.80 (CI, 5.93 to 2.33); P = 0.39

n/a

n/a