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Table 3 Patient characteristics at 30 days: comparison of survivors versusnon-survivors

From: Physiological predictors of survival during high-frequency oscillatory ventilation inadults with acute respiratory distress syndrome

Variable Survivors (number = 45) Non-survivors (number = 57)  
  Mean SD Mean SD P value
Demographics      
   Age, years 45.7 16.2 54.9 14.6 0.003
   Weight, Kg 75.8 22.7 75.6 20.2 ns
   APACHE II (prior to HFOV) 22.9 6.52 24.98 8.96 ns
   Murray Score 3.0 0.62 2.9 0.77 ns
   Duration ARDS prior to HFOV, days 2.9 3.6 4.5 4.7 0.015
   Duration CMV prior to HFOV, hours 88.9 131.9 90.4 105.9 ns
Gas exchange indices      
   PaO2/ FiO2 prior to HFOV, mmHg 96.8 38.8 90.8 38.3 ns
   PaO2/ FiO2 return to CMV, mmHg 211.5 96.0 129.0 70.5 0.001
   Δ PaO2 / FiO2 111.0 89.3 26.7 63.0 <0.01
   PaCO2 prior to HFOV, mmHg 54.0 20.8 60.8 17.0 ns
   PaCO2 return to CMV, mmHg 50.3 17.3 81.8 97.4 0.049
   OI prior HFOV, cmH2O· mmHg-1 26.1 13.4 27.6 13.4 ns
   OI return to CMV, cmH2O· mmHg-1 10.1 6.6 21.8 19.1 0.01
   Max PaCO2, mmHg 55.5 10.6 66.7 18.8 <0.01
   Min PaCO2, mmHg 36.0 6.7 47.9 16.0 <0.01
   pH prior to HFOV 7.3 0.14 7.23 0.12 <0.01
   pH return to CMV 7.4 0.1 7.27 0.1 <0.01
Hemodynamic indices      
   MAP prior to HFOV, mmHg 76.3 15.4 75.1 12.9 ns
   MAP return to CMV, mmHg 82.9 14.6 77.0 20.9 ns
   CO prior to HFOV, L · min-1 6.1 2.0 5.8 1.5 ns
   CO return to CMV, L ·min-1 5.9 1.3 6.1 0.5 ns
Ventilator Indices      ns
   Vt prior to HFOV, mL ·Kg-1 7.4 2.4 6.9 2.2 ns
   Vt return to CMV, mL ·Kg-1 6.9 2.1 6.8 1.9 ns
   PIP prior to HFOV, cmH2O 31.8 6.2 32.3 5.2 ns
   PIP return to CMV, cmH2O 28.5 5.2 30.3 5.98 ns
   PEEP prior to HFOV, cmH2O 12.9 4.0 12.1 3.4 ns
   PEEP return to CMV, cmH2O 10.5 2.7 10.8 3.3 ns
   CDP prior to HFOV, cmH2O 21.8 5.7 21.4 4.3 ns
   CDP return to CMV, cmH2O 17.5 4.5 20.7 5.9 0.02
   Δ CDP, cmH2O -3.9 6.5 -0.57 4.6 0.03
  1. CDP, continuous distending pressure; CMV, conventional mechanical ventilation;CO, cardiac output; FiO2, fraction of inspired oxygen; HFOV,high-frequency oscillatory ventilation; OI,Oxygenation Index (OI =(FiO2•CDP•100)/PaO2); PAWP, pulmonaryartery wedge pressure; PEEP, positive end-expiratory pressure; PIP, peakinspiratory pressure; Vt, tidal volume; = change post-HFOV to pre-HFOV.