Cortisol levels and neuropsychiatric diagnosis as markers of postoperative delirium:a prospective cohort study

Table 4 Variables related to anesthesia and surgery analyzed in univariate analysis

Variable	Nondelirious (n= 72)	Delirious (n= 41)	Odds ratio (95% CI)	P value
Dose of midazolam during surgery (mg)	46.2 (35 to 50)	50 (45 to 50)	1.04 (1.01 to 1.08)	0.011
Duration of surgery (hours)	3 (2.5 to 3.5)	3.5 (3 to 4)	1.06 (0.83 to 1.35)	0.051
Hemoglobin concentration^{a, b} (mg/dl)	8.9 (7.8 to 10.7)	7.9 (6.5 to 8.6)	0.66 (0.53 to 0.84)	0.0001
PaCO2 ≥ 45^{c, d} (mmHg)	17 (23.6%)	19 (46.3%)	2.79 (1.25 to 6.27)	0.013
PaO2 ≤ 60^{c, d} (mmHg)	13 (18.06%)	25 (60.98%)	7.09 (3.10 to 16.21)	< 0.0001
Aortic cross-clamping^a (minutes)	485 (415 to 622)	519 (435 to 675)	1.01 (0.99 to 1.02)	0.100

Data presented as n (%); for continuous variables the median andinterquartile range is given. CI, confidence interval. ^aIntraoperativevariable. ^bThe lowest intraoperative hemoglobin concentration wasrecorded and entered into the analysis. ^cPostoperative variable.^dBoth the one-time and multiple or sustained increase of partialpressure of carbon dioxide in arterial blood (PaCO₂) ≥ 45 mmHgand the drop of partial pressure of oxygen in arterial blood (PaO₂)≤ 50 mmHg were recorded and entered into the analysis.

ISSN: 1364-8535