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Table 1 Characteristics of healthy and polymicrobial infected mice

From: Impact of sepsis-associated cytokine storm on plasma NGAL during acute kidney injury in a model of polymicrobial sepsis

Sepsis characteristics

Healthy

6 h sepsis

24 h sepsis

P-value

WBC (× 103/μl)

5.45 (4.58-5.9)

1.85 (1.7-2.18)***

0.7 (0.6-1.23)***

<0.0001

Platelet count (× 103/μl)

1,238 (1,205-1,339)

1,002 (844-1,100)***

470 (399.8-603.5)***

<0.0001

LDH (U/l)

335 (296-375.5)

462 (388-585)**

545.5 (456.3-671.3)***

<0.0001

ASAT (U/l)

41.5 (38-47.5)

77.5 (64.25-108.3)***

123.5 (96.25-157)***

<0.0001

ALAT (U/l)

20.5 (19-22.75)

32.5 (26.25-45)**

33.5 (24.25-46.25)**

<0.001

Bacterial burden kidneys (CFU)

 

0 (0-275)

7,650 (575-24,350)

<0.0001

Bacterial burden blood (CFU)

 

15 (0-65)

20,800 (1,050-68,900)

<0.001

  1. Data are presented as median ± interquartile range. Investigated clinical chemistries from plasma samples of healthy controls (n = 16 to 20) and of polymicrobial infected mice 6 h (n = 16 to 20) and 24 h (n = 16 to 20) post-sepsis induction as well as bacterial burden from whole blood (6 and 24 h; n = 24). Statistically significant difference compared with healthy controls by ANOVA: **P ≤ 0.01, *** P ≤ 0.001. ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; CFU, colony forming units; LDH, lactate dehydrogenase; WBC, white blood cells.
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Critical Care

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