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Table 1 Characteristics of healthy and polymicrobial infected mice

From: Impact of sepsis-associated cytokine storm on plasma NGAL during acute kidney injury in a model of polymicrobial sepsis

Sepsis characteristics Healthy 6 h sepsis 24 h sepsis P-value
WBC (× 103/μl) 5.45 (4.58-5.9) 1.85 (1.7-2.18)*** 0.7 (0.6-1.23)*** <0.0001
Platelet count (× 103/μl) 1,238 (1,205-1,339) 1,002 (844-1,100)*** 470 (399.8-603.5)*** <0.0001
LDH (U/l) 335 (296-375.5) 462 (388-585)** 545.5 (456.3-671.3)*** <0.0001
ASAT (U/l) 41.5 (38-47.5) 77.5 (64.25-108.3)*** 123.5 (96.25-157)*** <0.0001
ALAT (U/l) 20.5 (19-22.75) 32.5 (26.25-45)** 33.5 (24.25-46.25)** <0.001
Bacterial burden kidneys (CFU)   0 (0-275) 7,650 (575-24,350) <0.0001
Bacterial burden blood (CFU)   15 (0-65) 20,800 (1,050-68,900) <0.001
  1. Data are presented as median ± interquartile range. Investigated clinical chemistries from plasma samples of healthy controls (n = 16 to 20) and of polymicrobial infected mice 6 h (n = 16 to 20) and 24 h (n = 16 to 20) post-sepsis induction as well as bacterial burden from whole blood (6 and 24 h; n = 24). Statistically significant difference compared with healthy controls by ANOVA: **P ≤ 0.01, *** P ≤ 0.001. ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; CFU, colony forming units; LDH, lactate dehydrogenase; WBC, white blood cells.