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Table 5 Negative predictive value of plasma MMP8 in combination with D-dimer.

From: Rule out of acute aortic dissection with plasma matrix metalloproteinase 8 in the emergency department

NPV

 

D-dimer (µg/ml)

 

AND

Any value

<0.5

<1.0

<2.0

 

<3.6

100%

TN 7, FN 0

100%

TN 1, FN 0

100%

TN 1, FN 0

100%

TN 3, FN 0

MMP8 (ng/ml)

<11.0

84.2%

TN 32, FN 6

100%

TN 12, FN 0

100%

TN 14, FN 0

100%

TN 22, FN 0

 

<30.0

73.2%

TN 52, FN 19

94.1%

TN 16, FN 1

95.5%

TN 21, FN 1

93.9%

TN 31, FN 2

 

Any value

 

95.2%

TN 20, FN 1

96.6%

TN 28, FN 1

93.3%

TN 42, FN 3

  1. Three representative cutoffs are presented for each biomarker. NPV, negative predictive value (%); TN, true negatives; FN, false negatives; MMP, matrix metalloproteinase.