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Table 4 ROC analysis for plasma MMP8, D-dimer and their combination.

From: Rule out of acute aortic dissection with plasma matrix metalloproteinase 8 in the emergency department

 

AUC

(95% CI)

Cutoff

Sensitivity %

(95% CI)

Specificity %

(95% CI)

MMP8

0.75a,b,c

(0.66-0.84)

>3.6

ng/ml

100%

(93.2%-100.0%)

9.5%

(3.9%-18.5%)

DD

0.87a

(0.80-0.94)

>0.50

µg/ml

97.6%

(87.4%-99.9%)

32.8%

(21.3%-46.0%)

DD*MMP8

0.87b

(0.80-0.94)

>2.44

100%

(91.6%-100.0%)

16.4%

(8.2%- 28.1%)

DD*log2(MMP8)

0.89c

(0.82-0.95)

>0.77

100%

(91.6%-100.0%)

13.1%

(5.8%- 24.2%)

  1. aP = 0.048, bP = 0.034, cP = 0.018. AUC, area under the curve; DD, D-dimer; MMP, matrix metalloproteinase; ROC, receiver-operating characteristics.
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Critical Care

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