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Table 3 Variables associated with plasma thrombomodulin by univariate and multivariate (backwards selection) linear regression analysis in 571 consecutive STEMI patients treated with primary PCI

From: Acute myocardial infarction is associated with endothelial glycocalyx and cell damage and a parallel increase in circulating catecholamines

  

Univariate

  

Multivariate

  
     

R 2 = 0.19

  
  

β (95%CI)

t

P

β (95%CI)

t

P

Adrenaline

100 pg/ml

0.03 (0.02 to 0.05)

4

<0.0001

0.02 (0.01 to 0.03)

3

0.003

Noradrenaline

100 pg/ml

0.01 (0.00 to 0.02)

3

0.006

  

NS

Age

years

0.02 (0.02 to 0.03)

6

<0.0001

  

NS

Male gender

yes

-0.37 (-0.60 to-0.15)

-3

0.001

  

NS

BMI

kg/m2

-0.03 (-0.06 to-0.01)

-3

0.002

-0.04 (-0.06 to-0.02)

-4

0.001

Current smoker

yes

-0.41 (-0.61 to-0.21)

-4

<0.0001

  

NS

Diabetes

yes

0.38 (0.04 to 0.72)

2

0.029

0.45 (0.13 to 0.76)

3

0.006

eGFR

ml/min

-0.02 (-0.02 to-0.02)

-10

<0.0001

-0.02 (-0.02 to-0.01)

-10

<0.0001

Peak TnI

µg/L

0.00 (0.00 to 0.00)

3

0.008

  

NS

Multivessel disease

yes

0.32 (0.10 to 0.55)

3

0.004

  

NS

  1. Regression coefficients (β) with 95% confidence intervals (95%CI), t-and P-values and R2 displayed for the multivariate models. P-values are shown in bold for variables with P <0.05. Predicted change in thrombomodulin (pg/ml) associated with one unit increase in adrenaline, noradrenaline, age, BMI, eGFR and peak TnI, being male, smoker or having diabetes or multivessel disease. BMI, body mass index; eGFR, estimated glomerular filtration rate; PCI, primary coronary intervention; STEMI, ST elevation myocardial infarction; TnI, troponin I.