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Table 3 NGAL (T0) values on the basis of diagnosed AKI by RIFLE criteria, AKIN criteria (48 hrs sCr increase), oliguria with two NGAL thresholds (≥150 ng/ml and ≥400 ng/ml).

From: Additive value of blood neutrophil gelatinase-associated lipocalin to clinical judgement in acute kidney injury diagnosis and mortality prediction in patients hospitalized from the emergency department

 

Threshold ≥150 ng/ml

(n= 160 patients: AKI n= 30/NO AKI n= 130)

Threshold ≥400 ng/ml

(n= 34 patients: AKI n= 18/NO AKI n= 16)

 

Sensitivity

(95% CI)

Specificity

(95% CI)

OR

(95% CI)

PPV

NPV

AUC

P

Sensitivity

(95% CI)

Specificity

(95% CI)

OR

(95% CI)

PPV

NPV

AUC

P

DIAGNOSIS OF AKI

              

RIFLE AKI

0.62

(0.48-0.74)

0.78

(0.75-0.82)

6.24

(3.37-11.55)

0.18

0.96

0.79

<0.001

0.37

(0.25-0.51)

0.97

(0.95-0.98)

22.53

(10.46-48-51)

0.52

0.95

0.79

<0.001

AKIN CRITERIA

(48 hrs sCr increase)

0.70

(0.39-0.89)

0.77

(0.73-0.80)

7.82

(1.99-30.65)

0.04

0.99

0.84

<0.001

0.40

(0.16-0.68)

0.95

(0.94-0.97)

15.46

(4.10-58.30)

0.13

0.99

0.84

<0.001

OLIGURIA

(<0.5 ML/kg/body weight in 6 hrs)

0.78

(0.52-0.92)

0.77

(0.73-0.80)

12.32

(3.39-44.75)

0.07

0.99

0.81

<0.001

0.42

(0.21-0.67)

0.95

(0.93-0.97)

16.42

(5.33-50.53)

0.17

0.98

0.81

<0.001

  1. AKI, acute kidney injury; AKIN, Acute Kidney Injury Network; AUC, area under the curve; CI, confidence interval; ED, emergency department; EDTA, NGAL, neutrophil gelatinase-associated lipocalin; NPV, negative predictive value; OR, odds ratio; PPV, positive predictive value; RIFLE criteria, Risk, Injury, Failure, Loss, and End-Stage Kidney Disease criteria.