Table 1 Baseline, donor, and outcome characteristics for 198 transplanted critically ill cirrhosis patients (first objective, five sites) and 106 nontransplanted critically ill cirrhosis patients (second objective, two sites)
From: Liver transplantation in the critically ill: a multicenter Canadian retrospective cohort study
| Â | First objective (n= 198) | Second objective (n= 106) |
|---|---|---|
Age (years) | 53 (10) | 54 (9.5) |
Female | 67 (34%) | 31 (29%) |
Etiology | Â | Â |
Hepatitis C | 62 (31%) | 30 (29%) |
Hepatitis B | 17 (9%) | 7 (7%) |
Alcohol | 30 (15%) | 24 (23%) |
PSC/PBC | 30 (15%) | 9 (9%) |
NASH/Cryptogenic | 17 (9%) | 18 (17%) |
Comorbidities/Cirrhotic complications | Â | Â |
Charlson Score | 1 (1) | 0.7 (1) |
Ascites | 100 (96%) | 61 (71%) |
Variceal bleeding | 53 (56%) | 54 (64%) |
Hepatic encephalopathy | 107 (94%) | 67 (79%) |
Hepatorenal syndrome | 84 (63%) | 71 (69%) |
Spontaneous bacterial peritonitis | 34 (41%) | 37 (44%) |
Hematology | Â | Â |
Hemoglobin (g/L) | 85 (23) | 84 (22) |
White blood count (×109/L) | 8.9 (5.2-14.5) | 9.7 (6.5-15.4) |
Platelet count (×109/L) | 64 (43-95) | 70 (40-118) |
Biochemistry | Â | Â |
INR | 2.1 (1.7-2.8) | 2.2 (1.8-3.3) |
ALT (U/L) | 46 (25-82) | 53 (27-128) |
Bilirubin (μM) | 273 (95-575) | 239 (95-469) |
Sodium (mM) | 137 (130-143) | 136 (130-143) |
Lactate (mM) | 2.8 (1.6-4.6) | 3.6 (2.4-7.8) |
pH | 7.39 (7.32-7.46) | 7.36 (7.25-7.44) |
Creatinine (μM) | 197 (109-308) | 207 (122-301) |
Physiology | Â | Â |
Mean arterial pressure (mm Hg) | 67 (60-83) | 52 (10) |
Glasgow Coma Scale score (admission) | 10 (5) | 9 (5) |
PO2/FiO2 ratio (mm Hg, admission) | 227 (106) | 195 (112) |
Organ support | Â | Â |
Vasopressors (admission) | 84/186 (45%) | 54/85 (64%) |
Vasopressors (any day) | 95/108 (88%) | 58/74 (78%) |
Mechanical ventilation (admission) | 76/134 (57%) | 50/86 (58%) |
MV (any day) | 100/114 (88%) | 61/74 (82%) |
RRT (admission) | 49/187 (26%) | 27/87 (31%) |
RRT (any day) | 78/139 (56%) | 42/76 (55%) |
Aggregate scores | Â | Â |
Child Turcotte Pugh (listing) | 12.4 (1.6) | Â |
MELD (listing) | 24 (16-36) | 23 (15-35) |
MELD (admit) | 34 (26-39) | 36 (27-40) |
MELD (transplant) | 34 (27-40) | Â |
SOFA (admit) | 12.5 (4) | 14 (4) |
SOFA (48 hours) | 13 (5) | 17 (4) |
SOFA (transplant) | 14 (4) | Â |
Mortality | Â | Â |
90 days | 32 (16%) | Â |
1 year | 52 (26%) | Â |
3 years | 63 (38%) | Â |
Donor characteristics | Â | Â |
Donor age >60 | 35 (18%) | Â |
Partial graft (split) | 2 (1%) | Â |
Donor cerebrovascular accident | 105 (54%) | Â |
Cold ischemia time >8 hours | 102 (56%) | Â |
Donor score (of 4) | 1 (1-2) | Â |