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Table 4 Univariate and multivariate analysis for predicting mortality in patients with severe community-acquired pneumonia

From: Plasma kallistatin levels in patients with severe community-acquired pneumonia

Variables

P value

OR

95% CI

Univariate analysis

   

   Age >76 years

0.436

1.647

0.470-5.778

   Gender (male)

0.437

0.605

0.170-2.148

   Kallistatin >8.3 μg/ml

0.034a

0.213

0.051-0.890

   Kallikrein >203.4 pg/ml

0.343

1.853

0.518-6.629

   Protein C >57.6%

0.991

1.008

0.288-3.521

   Antithrombin III >72.9%

0.170

0.386

0.099-1.501

   TNF-α >4.2 pg/ml

0.869

1.111

0.318-3.881

   IL-1β >0.6 pg/ml

0.343

1.853

0.518-6.629

   IL-6 >90.2 pg/ml

0.343

1.853

0.518-6.629

   IL-8 >33.4 pg/ml

0.034a

4.706

1.124-19.704

   CRP >129.5 μg/ml

0.750

0.816

0.234-2.851

   CURB-65 score >3

0.005a

8.056

1.880-34.516

   SOFA score >6

0.034a

4.706

1.124-19.704

   APACHE II score >19

0.161

2.500

0.694-9.005

Multivariate analysis

   

   Kallistatin >8.3 μg/ml

0.056b

0.114

0.012-1.058

   Antithrombin III >72.9%

0.457

2.262

0.264-19.390

   IL-8 (pg/ml) >33.4 pg/ml

0.130

6.854

0.568-82.733

   CURB-65 score >3

0.009b

29.850

2.356-378.246

   SOFA score >6

0.589

1.760

0.226-13.684

   APACHE II score >19

0.182

0.213

0.0220-2.067

  1. APACHE II, Acute Physiology and Chronic Health Evaluation II; CI, confidence interval; CRP, C-reactive protein; CURB-65, confusion of new onset (defined as an abbreviated mental test score of 8 or less), urea >7 mM (19 mg/dl), respiratory rate of 30 breaths per minute or greater, blood pressure <90 mm Hg systolic or diastolic blood pressure 60 mm Hg or less, and age 65 years or older; IL, interleukin; OR, odds ratio; TNF-α, tumor necrosis factor-α. aStatistically significant in univariate analysis. bStatistically nearly significant or significant in multivariate analysis.