Plasma kallistatin levels in patients with severe community-acquired pneumonia

Table 3 Comparisons of plasma biomarkers between survivors and nonsurvivors of severe community-acquired pneumonia

Variables	Survivors (n= 41)	Nonsurvivors (n= 13)	P value
Kallistatin (μg/ml)
Day 1	8.7 (3.0-17.3)	6.5 (1.3-16.2)	0.049^a
Day 4	11.7 (2.1-18.3)	7.3 (1.8-11.3)	0.002^a
Kallikrein (pg/ml)
Day 1	216.6 (29.9-4,459.9)	172.0 (16.5-4,085.0)	0.436
Day 4	169.9 (8.6-3,103.1)	126.8 (50.4-3,307.4)	0.738
Protein C (%)
Day 1	57.6 (11.3-104.0)	58.0 (19.4-251.4)	0.485
Day 4	76.0 (18.9-126.6)	54.7 (15.5-78.0)	0.013^a
Antithrombin III (%)
Day 1	76.0 (30.8-122.6)	62.5 (22.1-86.2)	0.037^a
Day 4	84.0 (34.4-112.6)	60.8 (27.0-87.2)	0.004^a
TNF-α (pg/ml)
Day 1	4.2 (0.7-497.1)	7.7 (1.1-249.2)	0.307
Day 4	9.1 (1.2-395.9)	20.4 (2.0-2,630.8)	0.100
IL-1β (pg/ml)
Day 1	0.6 (0.0-5.5)	0.8 (0.1-12.1)	0.390
Day 4	0.7 (0.0-14.1)	1.1 (0.5-2.3)	0.127
IL-6 (pg/ml)
Day 1	78.1 (5.5-600.0)	197.7 (7.4-600.0)	0.108
Day 4	53.0 (3.2-257.6)	181.2 (17.3-600.0)	0.052
IL-8 (pg/ml)
Day 1	25.2(2.4-592.0)	69.7 (18.3-4,000.0)	0.005^b
Day 4	18.0 (2.5-160.5)	60.4 (20.8-907.0)	0.003^b
CRP (μg/ml)
Day 1	124.9 (9.7-433.0)	113.9 (42.9-339.5)	0.833
Day 4	57.6 (7.0-229.5)	127.6 (21.7-313.4)	0.148

Data are expressed as median (range). CRP, C-reactive protein; IL, interleukin; TNF-α, tumor necrosis factor-α. ^aSignificantly lower in nonsurvivors. ^bSignificantly higher in nonsurvivors.

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