Effects of an angiotensin II antagonist on organ perfusion during the post-resuscitation phase in pigs

Table 5 Hepatic venous blood gases (mean ± SEM) pre-arrest and during the post-resuscitation phase

	Group	Pre-arrest	Post-resuscitation phase				Friedmann
			5 min	30 min	90 min	240 min
pH hep ven	TELM	7.42 ± 0.01	7.21 ± 0.02*	7.29 ± 0.02	7.40 ± 0.01	7.44 ± 0.01	P < 0.0001
	Control	7.42 ± 0.01	7.24 ± 0.01*	7.31 ± 0.01	7.39 ± 0.01	7.43 ± 0.01	P < 0.001
PHVO₂	TELM	37.9 ± 1.6	29.4 ± 3.2	36.3 ± 1.8	34.4 ± 3.8	33.4 ± 1.7	ns
(mmHg)	Control	34.7 ± 2.8	28.2 ± 3.3	31.7 ± 2.3	31.2 ± 2.0	29.1 ± 2.9	ns
PHVCO₂	TELM	45.1 ± 1.1	57.7 ± 1.7*	52.1 ± 2.4	45.7 ± 1.1	45.9 ± 0.8	P < 0.0001
(mmHg)	Control	46.3 ± 1.5	58.9 ± 1.6*	54.0 ± 1.6	47.2 ± 0.8	45.8 ± 0.9	P < 0.001
BE	TELM	4.5 ± 0.5	-5.3 ± 1.0*	-1.8 ± 1.1	2.9 ± 1.3	6.1 ± 0.6	P < 0.0001
	Control	4.9 ± 0.4	-3.1 ± 0.4*	+0.1 ± 0.9	4.0 ± 1.4	5.7 ± 1.0	P < 0.001

pH hep ven = hepatic venous pH; PHVO₂ = hepatic venous partial pressure of oxygen; PHVCO₂ = hepatic venous partial pressure of carbon dioxide; BE = base excess; TELM = angiotensin II antagonist telmisartan; ns = not significant. *P < 0.05 vs pre-arrest values by Wilcoxon matched pairs test.

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