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Table 2 Splanchnic organ blood flow (mean ± SEM) pre-arrest and during the post-resuscitation phase before and after drug administration

From: Effects of an angiotensin II antagonist on organ perfusion during the post-resuscitation phase in pigs

 

Group

Pre-arrest

Post-resuscitation phase

Friedmann

   

5 min

30 min

90 min

240 min

 

Liver

TELM

0.79 ± 0.14

0.63 ± 0.13*

0.78 ± 0.14

0.75 ± 0.15

1.10 ± 0.10*

P < 0.05

   (ml/min/g)

Control

0.68 ± 0.2

0.46 ± 0.09*

0.58 ± 0.09

0.81 ± 0.09

0.93 ± 0.20*

P < 0.01

Spleen

TELM

3.45 ± 0.59

0.53 ± 0.15*

3.45 ± 0.76

3.99 ± 0.67

3.49 ± 0.39

P < 0.01

   (ml/min/g)

Control

3.60 ± 0.26

0.77 ± 0.37*

4.44 ± 0.59

4.89 ± 0.41

3.82 ± 0.40

P < 0.001

Stomach

TELM

0.29 ± 0.06

0.08 ± 0.01*

0.17 ± 0.02

0.23 ± 0.03

0.30 ± 0.04

P < 0.001

   (ml/min/g)

Control

0.23 ± 0.03

0.06 ± 0.01*

0.16 ± 0.02

0.20 ± 0.02

0.28 ± 0.04

P < 0.0001

Pancreas

TELM

0.26 ± 0.01

0.05 ± 0.01*

0.18 ± 0.01

0.37 ± 0.04

0.55 ± 0.05*

P < 0.00001

   (ml/min/g)

Control

0.25 ± 0.04

0.05 ± 0.01*

0.15 ± 0.02

0.31 ± 0.05

0.48 ± 0.05*

P < 0.00001

Jejunum

TELM

0.37 ± 0.03

0.20 ± 0.02*

0.36 ± 0.03

0.41 ± 0.04

0.55 ± 0.05*

P < 0.0001

   (ml/min/g)

Control

0.44 ± 0.02

0.23 ± 0.02*

0.41 ± 0.04

0.42 ± 0.02

0.52 ± 0.04*

P < 0.001

Colon

TELM

0.40 ± 0.03

0.20 ± 0.02*

0.48 ± 0.04

0.51 ± 0.03

0.57 ± 0.03*

P < 0.00001

   (ml/min/g)

Control

0.49 ± 0.07

0.25 ± 0.04*

0.61 ± 0.08

0.61 ± 0.07

0.57 ± 0.09*

P < 0.0001

Kidney

TELM

3.40 ± 0.10

2.36 ± 0.41

2.67 ± 0.21

3.85 ± 0.30

4.62 ± 0.22*

P < 0.0001

   (ml/min/g)

Control

3.40 ± 0.21

2.50 ± 0.41

2.82 ± 0.11

3.80 ± 0.22

4.63 ± 0.16*

P < 0.001

Adrenal gland

TELM

1.69 ± 0.20

6.36 ± 1.56*

3.11 ± 0.81

2.01 ± 0.21

2.43 ± 0.35*

P < 0.05

   (ml/min/g)

Control

1.70 ± 0.09

5.09 ± 0.97*

2.14 ± 0.16

2.51 ± 0.24

2.19 ± 0.22

P < 0.05

  1. TELM = angiotensin II antagonist telmisartan; *P < 0.05 vs pre-arrest values by Wilcoxon matched pairs test.