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Table 1 Hemodynamic variables, and myocardial and cerebral blood flow (mean ± SEM) pre-arrest, and during the post-resuscitation phase before and after drug administration

From: Effects of an angiotensin II antagonist on organ perfusion during the post-resuscitation phase in pigs

Variable

Group

Pre-arrest

Post-resuscitation phase

Friedmann

   

5 min

30 min

90 min

240 min

 

MAP

TELM

114 ± 4

91 ± 7*

84 ± 3

91 ± 3

    90 ± 2*

P < 0.01

   (mmHg)

Control

  122 ± 11

  93 ± 12*

91 ± 4

93 ± 4

    92 ± 4*

P < 0.05

CI

TELM

115 ± 6

66 ± 7*

77 ± 7

98 ± 7

108 ± 5

P < 0.001

   (ml/min/kg)

Control

129 ± 9

72 ± 7*

77 ± 4

114 ± 14

  102 ± 5*

P < 0.001

LVMBF

TELM

    1.9 ± 0.2

2.6 ± 0.4

  1.3 ± 0.1

  2.1 ± 0.4

    2.3 ± 0.5

P < 0.05

   (ml/min/g)

Control

    2.1 ± 0.3

2.3 ± 0.3

  1.4 ± 0.1

  2.4 ± 0.3

    2.6 ± 0.5

ns

Cortex

TELM

    0.36 ± 0.02

  2.10 ± 0.36*

  0.29 ± 0.02

  0.32 ± 0.03

      0.57 ± 0.14*

P < 0.0001

   (ml/min/g)

Control

    0.38 ± 0.03

  2.27 ± 0.31*

  0.36 ± 0.02

  0.44 ± 0.07

      0.57 ± 0.05*

P < 0.001

  1. CI = cardiac index; LVMBF = left ventricular myocardial blood flow; MAP = mean arterial pressure; ns = not significant; TELM = angiotensin II antagonist telmisartan. *P < 0.05 vs pre-arrest values by Wilcoxon matched pairs test.
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