From: Clinical review: Statins and trauma - a systematic review
Study | Design | Participants | Intervention | Comparisons | Outcome | Results | Subgroup analyses | Remarks |
---|---|---|---|---|---|---|---|---|
Akcay et al. (2005) [33] | Clinical trial | 20 patients with severe burns, treated in a single centre | Atorvastatin, 20 mg once daily, orally, for 14 days (n = 10) | Placebo (n = 10) | Plasma E-selectin | 23.69 ng/ml (intervention group), 18.08 ng/ ml (control group) on enrolment; 10.86 ng/ ml and 21.69 ng/ml, respectively, after 14 days (P < 0.05) | Â | Â |
Tapia-Perez et al. (2008) [31] | Double blind randomised controlled trial, designated as 'pilot' | 21 patients aged between 16 and 50 years with traumatic brain injury, GCS 9-13 and intracranial lesion on CT scan | Rosuvastatin, 20 mg once daily, for 10 days (n = 8) | Placebo (n = 13) | Reduction in amnesia time (measured using Galveston Orientation and Amnesia Test) | HR 53.76 (95% CI 1.58-1,824.64) | Â | Despite randomisation, due to small numbers, the groups were not homogenous with regard to neurological parameters, with possibly more severe injury in treatment group |
Patil et al. (2009) [46] | Double blind, placebo-controlled, randomised controlled trial | Patients with undisplaced, extra-articular distal radial fractures | Simvastatin, 20 mg, once daily (n = 31) | Placebo (n = 31) | Mean time to fracture union Mean percentage trabecular healing at 12 weeks post-injury | Simvastatin group, 71.7 days; control group, 71.3 days (P = 0.6481) Simvastatin group, 85%; control group, 87% (P = 0.431) | Â | Low dose simvastatin used. No measures of simvastatin levels reported |