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Figure 1 | Critical Care

Figure 1

From: Cyclic arginine-glycine-aspartate attenuates acute lung injury in mice after intestinal ischemia/reperfusion

Figure 1

cRGD attenuates gut damage and microscopic deterioration of gut after intestinal ischemia/reperfusion. Mice treated with normal saline or cyclic arginine-glycine-aspartate peptide (cRGD) were subjected to intestinal ischemia/reperfusion (I/R). After 4 hours, mice were euthanized. (A) Representative images for the gross morphological appearance of the gut from sham, vehicle, and cRGD treatment groups. (B) Gut tissues harvested 4 hours after intestinal I/R were stained with H & E, and examined under light microscopy at 200× magnification. Representative images for sham, vehicle, and cRGD treatment groups. (C) Histologic injury scores of the gut in different groups were quantified as described in Materials and methods. (D) Gut tissue myeloperoxidase (MPO) activity was determined spectrophotometrically. Data expressed as mean ± standard error (n = 5/group). *P < 0.05 versus sham, #P < 0.05 versus vehicle. ND, nondetectable.

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