Lower tidal volume at initiation of mechanical ventilation may reduce progression to acute respiratory distress syndrome: a systematic review

Table 3 Clinical outcomes comparing ARDS and non-ARDS groups

Outcome	Author, year	ARDS	No ARDS	p
Mortality	Kahn, 2006	42%	19%	<0.05
	Fernandez-Perez, 2009	44%	8%	<0.001
	Mascia, 2007	28%	22%	NS
Hospital mortality	Gajic, 2004	34%	24%	0.116
	Gajic, 2005	62%	32%
	Iscimen, 2008	51%	18%	<0.001
	Fernandez-Perez, 2009	17%	5%	0.004
ICU mortality	Iscimen, 2008	38%	11%
ICU LOS (days)	Mascia, 2007	25	20	<0.05
	Kahn, 2006	15% increase		<0.05
Hospital LOS (days)	Kahn, 2006	7% increase		NS
	Fernandez-Perez, 2009	17	5	<0.001
VF days	Gajic, 2004	17	22	0.007
	Mascia, 2007	11	16	<0.05
Duration of MV (days)	Kahn, 2006	14	8	<0.001
Renal failure	Kahn, 2006	8%	2%	<0.001

ARDS, acute respiratory distress syndrome; LOS, length of stay; MV, mechanical ventilation; NS, nonsignificant; VF, ventilator free.

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