Randomized controlled trial | |||||||
---|---|---|---|---|---|---|---|
Author, year | Time of ARDS onset | Incidence of ARDS | Experimental ARDS rate | Control ARDS rate | OR | p | Commentsa |
Determann, 2010 | 1.9 days | 8% (n =12) | 2.6% (n = 2) | 13.5% (n = 10) | 5.1 (1.2-22.6) | 0.01 | Trial stopped early for safety, due to ARDS in control. |
Observational studies | |||||||
Cohort studies | |||||||
Author, year | Time of ARDS onset | Incidence of ARDS | VT ARDS Group | VT No-ARDS Group | OR b | p | Comments |
Gajic, 2004 | 2.5 days | 24% (n = 80) | Unknown | Unknown | 1.29 (1.12-1.51) | <0.001 | Proportion of ARDS increased as VT increased. |
Gajic, 2005 | Unknown | 6.2% (n = 205) | 670 ml ± 220c | 620 ml ±110 c | 1.26 (1.12-1.40) | <0.001 | Proportion of ARDS increased as VT increased. |
Kahn, 2006 | 3 days | 27% (n = 170) | 9.1 ml/kg PBW ±1.8 | 9.4 ml/kg PBW ±1.5 | NS | 0.06 | ARDS development associated with transfusion, SAH severity, and PRBC transfusion. |
Mascia, 2007 | 2.8 days | 22% (n =18) | 10.4 ml/kg PBW ± 1.1b | 9.5 ml/kg PBW ±1.0c | 5.54 (1.54-9.24) | 0.008 | Proportion of ARDS increased as VT increased. |
Yilmaz, 2007â•‘ | Unknown | 28% (n = 60) before protocol; 10% (n = 17) after protocol | Unknown | Unknown | 1.31 (1.16-1.50) | <0.001 | Proportion of ARDS increased as VT increased. |
Plurad, 2007 | Unknown | 8.2% (n = 192) | 8.6 ml/kg PBW ± 1.7 | 8.8 ml/kg PBW ± 2.3 | NS | 0.383 | ARDS associated with fluid balance and PRBC transfusion |
Iscimen, 2008 | 5 hours | 44% (n = 71) | 6.9 ml/kg PBW (6.1-7.8) | 7.0 ml/kg PBW (6.5-7.9) | NS | 0.362 | Delayed antibiotics and resuscitation associated with ARDS |
Jia, 2008 | 3.3 days | 19% (n = 152) | 650.5 ml ± 119.7c | 616.9 ml ± 112.8c | 1.33 (1.09-1.62) | 0.006 | Proportion of ARDS increased as VT increased. Transfusion, fluid balance, airway pressures also associated with ARDS. Mean VT in patients that developed ARDS, 623.5 ml |
Pasero, 2008 | 3.7 days | 7% (n = 14) | Unknown | Unknown | 2.04 (1.03-4.05) | 0.042 | Time of surgery and PEEP also associated with ARDS |
Hughes, 2010 | Unknown | 28% (n = 25) | 9.0 ml/kg PBW (8.3-10.0) | 9.3 ml/kg PBW (8.3-10.1) | 1.0 (0.3-3.2) | 0.97 | Intraoperative fluid >20 ml/kg/h associated with ARDS |
Blum, 2011 | Unknown | 0.2% (n = 102) | 9.2 ml/kg PBWc | 9.1 ml/kg PBWc | 0.77 (0.62-0.95) | 0.02 | PRBC transfusion strongest predictor of ARDS |
Case-control study | |||||||
Author, year | Time of ARDS onset | Incidence of ARDS | VT ARDS Group | VT No-ARDS Group | OR d | p | Comments |
Fernandez-Perez, 2009 | Unknown | 1.9% (n = 83) | 8.9 ml/kg PBW ±1.6 | 8.7 ml/kg PBW ±1.7 | 1.03 (0.84-1.26) | 0.801 | Time of surgery, transfusion, and fluid balance associated with ARDS |