Table 2 Sites, causes of infection and adequate antibiotic treatment in patients with severe sepsis.
|  | Control group (n= 180) | Tα1 group (n= 181) | P value |
|---|---|---|---|
Sites of infection* | |||
   Lung | 133 (73.9%) | 136 (75.1%) | 0.79 |
   Abdomen | 48 (26.7%) | 51 (28.2%) | 0.75 |
   Urinary tract | 5 (2.8%) | 2 (1.1%) | 0.28 |
   Positive blood culture | 10 (5.6%) | 11 (6.1%) | 0.83 |
   Other†| 18 (10.0%) | 16 (8.8%) | 0.71 |
Results of pathogens | Â | Â | 0.99 |
   Pure gram-negative | 47 (26.1%) | 51 (28.2%) |  |
   Pure gram-positive | 15 (8.3%) | 14 (7.7%) |  |
   Pure fungus | 22 (12.2%) | 21 (11.6%) |  |
   Mixed | 57 (31.7%) | 56 (30.9%) |  |
   Culture negative | 39 (21.7%) | 39 (21.6%) |  |
Types of organisms‡ | |||
Gram-positive | Â | Â | Â |
   Staphylococcus aureus | 7 (3.9%) | 9 (5.0%) | 0.62 |
   Other staphylococcus species | 9 (5.0%) | 12 (6.6%) | 0.51 |
   Enterococcus species | 22 (12.2%) | 23 (12.7%) | 0.89 |
   Other gram-positive | 18 (10.0%) | 14 (7.7%) | 0.45 |
Gram-negative | Â | Â | Â |
   Klebsiella species | 18 (10.0%) | 22 (12.2%) | 0.51 |
   Escherichia coli | 25 (13.9%) | 23 (12.7%) | 0.74 |
   Pseudomonas species | 32 (17.8%) | 32 (17.7%) | 0.98 |
   Acinetobacter | 8 (4.4%) | 15 (8.3%) | 0.14 |
   Enterobacter species | 4 (2.2%) | 4 (2.2%) | 1.00 |
   Other gram-negative | 14 (7.8%) | 16 (8.8%) | 0.71 |
Fungus | Â | Â | Â |
   Candida albicans | 43 (23.9%) | 38 (21.0%) | 0.51 |
   Other candida species | 20 (11.1%) | 15 (8.3%) | 0.36 |
   Mould | 1 (0.6%) | 4 (2.2%) | 0.37 |
   Other fungus | 6 (3.3%) | 6 (3.3%) | 0.99 |
Empirical antibiotic therapy | Â | Â | 0.903 |
   Adequate | 136 (75.6%) | 133 (73.5%) |  |
   Inadequate | 34 (18.9%) | 37 (20.4%) |  |
   Not evaluable | 10 (5.6%) | 11 (6.1%) |  |