| Control group | Tα1 group | P value |
---|---|---|---|
n | 180 | 181 | Â |
Age (yr) | 66.4 ± 12.6 | 64.7 ± 14.5 | 0.46 |
Age group | Â | Â | 0.79 |
   < 50 yr | 21 (11.7%) | 24 (13.3%) |  |
   50-60 yr | 39 (21.7%) | 45 (24.9%) |  |
   61-70 yr | 39 (21.7%) | 39 (21.6%) |  |
   71-yr | 81 (45.0%) | 73 (40.3%) |  |
Male | 131 (72.8%) | 141 (77.9%) | 0.26 |
Female | 49 (27.2%) | 40 (22.1%) | Â |
BMI | 22.0 ± 3.0 | 22.2 ± 3.1 | 0.48 |
Prior or preexisting conditions | |||
   Congestive heart failure | 8 (4.4%) | 5 (2.8%) | 0.39 |
   Hypertension | 79 (43.9%) | 80 (44.2%) | 0.95 |
   Coronary heart disease | 19 (10.6%) | 22 (12.2%) | 0.63 |
   Liver disease | 10 (5.6%) | 9 (5.0%) | 0.80 |
   COPD | 28 (15.6%) | 29 (16.0%) | 0.90 |
   Nervous system diseases | 33 (18.3%) | 32 (17.7%) | 0.87 |
   Diabetes | 34 (18.9%) | 40 (22.1%) | 0.45 |
   Recent trauma | 8 (4.4%) | 8 (4.4%) | 0.99 |
   Cancer | 55 (30.6%) | 60 (33.2%) | 0.60 |
Recent surgical history | Â | Â | 0.47 |
   No history of surgery | 103 (57.2%) | 92 (50.8%) |  |
   Elective surgery | 41 (22.8%) | 46 (25.4%) |  |
   Emergency surgery | 36 (20.0%) | 43 (23.8%) |  |
Other indicators of disease severity | |||
   Mechanical ventilation | 143 (79.4%) | 146 (80.7%) | 0.77 |
   Shock | 74 (41.1%) | 64(35.4%) | 0.26 |
   Use of any vasopressor or dobutamine | 72 (40.0%) | 71(39.2%) | 0.88 |
   Low-dose corticoid | 18 (10.0%) | 20 (11.1%) | 0.75 |
   Blood transfusion | 54 (30.0%) | 64 (35.4%) | 0.28 |
Baseline acute organ dysfunctions | Â | Â | Â |
   Pulmonary | 170 (94.4%) | 172 (95.0%) | 0.80 |
   Renal | 48 (26.7%) | 53 (29.3%) | 0.58 |
   Cardiovascular | 113 (62.8%) | 124 (68.5%) | 0.25 |
   Hematologic | 69 (38.3%) | 67 (37.0%) | 0.80 |
   Hepatic | 39 (21.7%) | 27 (14.9%) | 0.10 |
Number of acute organ dysfunction | Â | Â | 0.97 |
   1 | 32 (17.8%) | 29 (16.0%) |  |
   2 | 75 (41.7%) | 77 (42.5%) |  |
   3 | 45 (25.0%) | 48 (26.5%) |  |
   4 | 18 (10.0%) | 19 (10.5%) |  |
   5 | 10 (5.6%) | 8 (4.4%) |  |
APACHE II score | 21.6 ± 7.7 | 22.3 ± 6.7 | 0.35 |
SOFA score | 7.7 ± 3.9 | 7.9 ± 3.6 | 0.65 |
   Respiratory system | 2.6 ± 1.0 | 2.7 ± 0.9 | 0.22 |
   Coagulation | 0.8 ± 1.1 | 1.0 ± 1.2 | 0.17 |
   Cardiovascular system | 1.4 ± 1.6 | 1.2 ± 1.5 | 0.40 |
   Liver | 0.6 ± 0.9 | 0.5 ± 0.8 | 0.38 |
   Nervous system | 1.3 ± 1.4 | 1.4 ± 1.4 | 0.69 |
   Renal system | 1.0 ± 1.3 | 1.0 ± 1.4 | 0.85 |
Time from first organ dysfunction to enrollment (hr) median(IQR) | 28.0 (15.0-48.0) | 42.0 (24.0-72.0) | 0.003 |