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Table 4 Demographic and model parameters applied to case studies

From: Combining creatinine and volume kinetics identifies missed cases of acute kidney injury following cardiac arrest

Parameter

Equations

Case A

Case B

Case C

Sex

 

Male

Male

Male

Weight, kg

 

90

87

80

APACHE II score

 

26

21

19

SOFA score

 

12

8

4

ROSC duration, minutes

 

50

20

27

Time from arrest to first in-hospital plasma creatinine, minutes

 

-91a

84

26

Total body water (TBW), mL

60 × weight in kg

54,000

52,200

48,000

Plasma volume (V10), mL

TBW/15

3,600

3,480

3,200

Creatinine compartment outside of plasma (V20)

TBW - plasma volume

50,400

48,720

44,800

Expandable space [16] (V2e 0), mL

Plasma volume × 3

10,800

10,740

9,600

Insensible loss rate (İ), mL/minute

(800 mL/day)

0.56

 

0.56

Metabolic production rate (), mL/minute

Insensible loss rate/2

0.28

 

0.28

Baseline creatinine production rate [38] (Ġ), mg/minute

(27 - 0.173 × age in years) × weight in kg/1,440

1.43

 

0.885

Distribution clearance (Cl d ), mL/minute

 

200

200

200

  1. aAs this patient arrested in the emergency department (ED), a baseline creatinine was available on entry to the ED, 91 minutes prior to cardiac arrest. APACHE II, Acute Physiology and Chronic Health Evaluation II; ROSC, return of spontaneous circulation; SOFA, Sequential Organ Failure Assessment.