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Table 4 Demographic and model parameters applied to case studies

From: Combining creatinine and volume kinetics identifies missed cases of acute kidney injury following cardiac arrest

Parameter Equations Case A Case B Case C
Sex   Male Male Male
Weight, kg   90 87 80
APACHE II score   26 21 19
SOFA score   12 8 4
ROSC duration, minutes   50 20 27
Time from arrest to first in-hospital plasma creatinine, minutes   -91a 84 26
Total body water (TBW), mL 60 × weight in kg 54,000 52,200 48,000
Plasma volume (V10), mL TBW/15 3,600 3,480 3,200
Creatinine compartment outside of plasma (V20) TBW - plasma volume 50,400 48,720 44,800
Expandable space [16] (V2e 0), mL Plasma volume × 3 10,800 10,740 9,600
Insensible loss rate (İ), mL/minute (800 mL/day) 0.56   0.56
Metabolic production rate (), mL/minute Insensible loss rate/2 0.28   0.28
Baseline creatinine production rate [38] (Ġ), mg/minute (27 - 0.173 × age in years) × weight in kg/1,440 1.43   0.885
Distribution clearance (Cl d ), mL/minute   200 200 200
  1. aAs this patient arrested in the emergency department (ED), a baseline creatinine was available on entry to the ED, 91 minutes prior to cardiac arrest. APACHE II, Acute Physiology and Chronic Health Evaluation II; ROSC, return of spontaneous circulation; SOFA, Sequential Organ Failure Assessment.