Combining creatinine and volume kinetics identifies missed cases of acute kidney injury following cardiac arrest

Table 4 Demographic and model parameters applied to case studies

Parameter	Equations	Case A	Case B	Case C
Sex		Male	Male	Male
Weight, kg		90	87	80
APACHE II score		26	21	19
SOFA score		12	8	4
ROSC duration, minutes		50	20	27
Time from arrest to first in-hospital plasma creatinine, minutes		-91^a	84	26
Total body water (TBW), mL	60 × weight in kg	54,000	52,200	48,000
Plasma volume (V₁₀), mL	TBW/15	3,600	3,480	3,200
Creatinine compartment outside of plasma (V₂₀)	TBW - plasma volume	50,400	48,720	44,800
Expandable space [16] (V_{2e 0}), mL	Plasma volume × 3	10,800	10,740	9,600
Insensible loss rate (İ), mL/minute	(800 mL/day)	0.56		0.56
Metabolic production rate (Ṁ), mL/minute	Insensible loss rate/2	0.28		0.28
Baseline creatinine production rate [38] (Ġ), mg/minute	(27 - 0.173 × age in years) × weight in kg/1,440	1.43		0.885
Distribution clearance (Cl_d), mL/minute		200	200	200

^aAs this patient arrested in the emergency department (ED), a baseline creatinine was available on entry to the ED, 91 minutes prior to cardiac arrest. APACHE II, Acute Physiology and Chronic Health Evaluation II; ROSC, return of spontaneous circulation; SOFA, Sequential Organ Failure Assessment.

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