Parameter | Equations | Case A | Case B | Case C |
---|---|---|---|---|
Sex | Male | Male | Male | |
Weight, kg | 90 | 87 | 80 | |
APACHE II score | 26 | 21 | 19 | |
SOFA score | 12 | 8 | 4 | |
ROSC duration, minutes | 50 | 20 | 27 | |
Time from arrest to first in-hospital plasma creatinine, minutes | -91a | 84 | 26 | |
Total body water (TBW), mL | 60 × weight in kg | 54,000 | 52,200 | 48,000 |
Plasma volume (V10), mL | TBW/15 | 3,600 | 3,480 | 3,200 |
Creatinine compartment outside of plasma (V20) | TBW - plasma volume | 50,400 | 48,720 | 44,800 |
Expandable space [16] (V2e 0), mL | Plasma volume × 3 | 10,800 | 10,740 | 9,600 |
Insensible loss rate (İ), mL/minute | (800 mL/day) | 0.56 | 0.56 | |
Metabolic production rate (Ṁ), mL/minute | Insensible loss rate/2 | 0.28 | 0.28 | |
Baseline creatinine production rate [38] (Ġ), mg/minute | (27 - 0.173 × age in years) × weight in kg/1,440 | 1.43 | 0.885 | |
Distribution clearance (Cl d ), mL/minute | 200 | 200 | 200 |