Changes in plasma creatinine concentration in the Cr
patients. (a) Median change in plasma creatinine concentration relative to the first creatinine measured in the emergency department for Crdecrease patients. Solid circles represent raw changes. Open white squares show changes after correction for fluid input and urine output by using the volume-creatinine kinetic model and assuming maintenance of glomerular filtration rate. Whiskers show interquartile range. (b) The median changes in creatinine production necessary to account for the observed reduction in plasma creatinine shown in panel (a). Crdecrease, group of patients with a plasma creatinine decrease of more than 10% at 24 hours after cardiac arrest.