Figure 3From: Combining creatinine and volume kinetics identifies missed cases of acute kidney injury following cardiac arrestSimulated changes in plasma creatinine in the presence of reduced glomerular filtration rate (GFR). Plasma creatinine in a 70-kg male according to a plasma creatinine generation rate of 1 mg/minute and a baseline plasma creatinine of 1 mg/dL. Values are shown following an infusion of crystalloid (a) or colloid (b) at 1 L/hour for 6 hours. In each scenario, the creatinine curves (dark lines) are plotted for no loss (0%) and 33.3%, 50%, and 66.7% loss of GFR (step change) at t = 1 hour. Dotted lines represent the corresponding theoretical change in creatinine if there was no accounting for fluid balance or the 1.5%/day creatinine production reduction due to muscle wasting. Dark shading represents acute kidney injury (AKI) by the RIFLE (Risk, Injury, Failure, Loss, and End-stage kidney disease) definition (> 50% increase in plasma creatinine above baseline), and light shading represents AKI by the AKIN (Acute Kidney Injury Network) definition alone (> 0.3 mg/dL increase in plasma creatinine above baseline).Back to article page