Figure 2

Simulated changes in plasma creatinine and plasma volume while glomerular filtration rate was maintained. Plasma volume (dotted lines) and plasma creatinine (solid lines) in a 70-kg male (total body water of 42 L) according to a plasma creatinine generation rate of 1 mg/minute and a baseline plasma creatinine of 1 mg/dL (equivalent to a creatinine clearance of 100 mL/minute) after an infusion of crystalloid (black lines) or colloid (grey lines) at 1 L/hour for 6 hours.