The anti-inflammatory effect of the synthetic antimicrobial peptide 19-2.5 in a murine sepsis model: a prospective randomized study

Table 3 Activity index, mean arterial pressure and heart rate after 24 hours of sepsis.

	Sham	Sepsis-control	polyB	Pep 2.5	Pep 4	Pep 8
Activity index (points)	1.1 ± 0.3^a	4.4 ± 0.8	3.2 ± 0.5^a	2.5 ± 0.7^a	4.0 ± 0.8	4.1 ± 0.7
Mean arterial pressure (mmHg)	149 ± 40	126 ± 65	100 ± 27	97 ± 38	92 ± 49	86 ± 29
Heart rate (1/minute)	485 ± 197^b	310 ± 88	364 ± 140	434 ± 196	297 ± 108	354 ± 125

^aP < 0.001 versus control; ^bP < 0.05 versus control. Activity index ranges from 1 (best activity) to 5 (agony). Sham, sham operation with vehicle infusion; Sepsis-control, sepsis with vehicle infusion; polyB, sepsis with PolymyxinB infusion; Pep 2.5, sepsis with peptide 19-2.5 infusion; Pep 4, Sepsis with peptide 19-4 infusion; Pep 8, sepsis with peptide 19-8 infusion; Data given as mean ± SD

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