Skip to main content

Advertisement

Table 2 Comparison of qualities between small and large trials in meta-analyses in critical care medicine.

From: Small studies may overestimate the effect sizes in critical care meta-analyses: a meta-epidemiological study

  No. of patients in component trials P value
  Large trials (>100 per arm, n = 73) Small trials (<100 per arm, n = 244)  
Sequence generating    0.031
   Adequate 29 (59%) 50 (41%)  
   Inadequate/unclear 20 (41%) 72 (59%)  
Allocation concealment    <0.001
   Adequate 56 (82%) 114 (51%)  
   Inadequate/unclear 12 (18%) 111 (49%)  
Blinding    <0.001
   Adequate 49 (67%) 99 (41%)  
   Inadequate/unclear 24 (33%) 145 (59%)  
Incomplete follow-up data addressed    <0.001
   Adequate 36 (86%) 56 (48%)  
   Inadequate/unclear 6 (14%) 61 (52%)  
Intention to treat    <0.001
   Yes 38 (83%) 79 (52%)  
   No/unclear 8 (17%) 72 (48%)  
Sample size calculation    <0.001
   Yes 29 (88%) 32 (44%)  
   No/unclear 4 (12%) 40 (56%)  
Year of publication    <0.001
   Before 2002 55 (75%) 127 (52%)  
   After 2002 18 (25%) 117 (48%)