Table 1 Characteristics of included meta-analyses.

Abroug F 2011 [9]

Prone ventilation

7

37.3

3 (42.9)

0.91 (0.75, 1.1)

0%

Afshari A 2007 [10]

Antithrombin III

20

39.9

1 (5)

0.96 (0.89, 1.03)

0%

Afshari A 2011 [11]

Inhaled nitric oxide for ARDS

14

38.6

3 (21.4)

1.06 (0.93, 1.22)

0%

Annane D 2009 [12]

Corticosteroids

20

36.4

4 (20)

0.87 (0.74, 1.01)

44%

Augustes R 2011 [13]

Sedation interruption

5

37.2

1 (20)

0.84 (0.58, 1.21)

19.4%

Barkun AN 2012 [14]

PPI for stress-related mucosal bleeding

8

18.7

3 (37.5)

1.19 (0.84, 1.68)

0%

Blackwood B 2011 [15]

Weaning protocol

10

14.7

5 (50)

0.98 (0.48, 2.02)

57%

Burns KE 2011 [16]

Volume-limited ventilation

10

42.5

2 (20)

0.84 (0.7, 1.0)

43.1%

Delaney AP 2011 [17]

Albumin for resuscitation

17

33.8

1 (5.9)

0.82 (0.67, 1.0)

0%

Kopterides P 2010 [18]

Procalcitonin-guided

6

22.6

1 (16.7)

0.93 (0.69, 1.26)

0%

Landoni G 2010 [19]

Levosimendan

27

22.4

3 (11.1)

0.74 (0.62, 0.89)

11.3%

Laupland KB 2007 [20]

Polyclonal intravenous immunoglobulin

14

41.8

2 (14.3)

0.66 (0.53, 0.83)

53.8%

Marik PE 2008 [21]

Immunonutrition

24

25.8

5 (20.8)

0.85 (0.64, 1.13)

44%

Phoenix SI 2009 [22]

High PEEP

6

38.5

3 (50)

0.87 (0.78, 0.96)

0%

Pileggi C 2011 [23]

Selective decontamination of the digestive or respiratory tract

11

NR

6 (54.5)

1.1 (0.98, 1.24)

0%

Puskarich MA 2009 [24]

Glucose-insulin-potassium infusion

23

9

5 (21.7)

1.02 (0.93, 1.11)

0%

Serpa Neto A 2012 [25]

Vasopressin/terlipressin

9

50.3

1 (11.1)

0.87 (0.79, 0.96)

0%

Shah MR 2005 [26]

Pulmonary artery catheter

13

32.7

4 (30.8)

1.04 (0.9, 1.2)

0%

Shan L 2011 [27]

Intensive insulin therapy

5

34.7

2 (40)

0.98 (0.82, 1.16)

0%

Siempos II 2010 [28]

Probiotics

4

19.5

1 (25)

0.75 (0.47, 1.21)

0%

Tan JA 2010 [29]

Dexmedetomidine

16

8.7

3 (18.8)

0.85 (0.64, 1.17)

0%

Vasu TS 2012 [30]

Dopamine/norepinephrine

6

54.0

2 (33.3)

0.43 (0.26, 0.69)

65.4%

Visser J 2011 [31]

Micronutrient supplementation

10

28.8

1 (10)

0.78 (0.67, 0.90)

0%

Wang F 2011 [32]

Timing of tracheotomy

7

33.0

2 (28.6)

0.86 (0.65, 1.13)

45%

Wang F 2012 [33]

Subglottic secretion drainage

9

22.1

3 (33.3)

0.97 (0.84, 1.12)

0%

Zarychanski R 2009 [34]

Hydroxyethyl starch resuscitation

10

31.1

1 (10)

1.07 (0.85, 1.34)

0%

Zhongheng Z 2010 [35]

Dose of CRRT

6

45.4

5 (83.3)

0.91 (0.77, 1.08)

75%