| Total patients (N= 3,746) | Not co-enrolled (N= 3,033) | Co-enrolled patients (N= 713) | P-value |
---|---|---|---|---|
Patient characteristics | ||||
Age, mean (SD) | 61.4 (16.5) | 61.4 (16.6) | 61.4 (15.9) | 0.996 |
Female, N (%)* | 1,614 (43.3) | 1,319 (43.8) | 295 (41.4) | 0.257 |
APACHE II score, mean (SD)** | 21.5 (7.8) | 21.1 (7.8) | 23.3 (7.6) | < 0.001 |
Medical admission type, N (%) | 2,831 (75.6) | 2,262 (74.6) | 569 (79.8) | 0.004 |
Person consenting, N (%)*** | ||||
Patient | 354 (9.5) | 335 (11.1) | 19 (2.7) | < 0.001 |
Substitute decision-maker | 3,380 (90.5) | 2,686 (88.9) | 694 (97.3) | Â |
Research coordinator characteristics | ||||
Years of non-research ICU experience, N (%) | ||||
0 years | 572 (15.3) | 491 (16.2) | 81 (11.4) | 0.003 |
> 0 to 10 years | 1,254 (33.5) | 1,017 (33.5) | 237 (33.2) | Â |
> 10 years | 1,920 (51.3) | 1,525 (50.3) | 395 (55.4) | Â |
Years of procuring consent for clinical studies in ICU, N (%) | ||||
0 years | 302 (8.1) | 268 (8.8) | 34 (4.8) | < 0.001 |
> 0 to 10 years | 2,652 (70.8) | 2,276 (75.0) | 376 (52.7) | Â |
> 10 years | 792 (21.1) | 489 (16.1) | 303 (42.5) | Â |
Center characteristics | ||||
Number of ICU beds screened, N (%) | ||||
< 15 beds | 420 (11.2) | 414 (13.6) | 6 (0.8) | < 0.001 |
15 to 20 beds | 1622 (43.3) | 1,218 (40.2) | 404 (56.7) | Â |
> 20 beds | 1,704 (45.5) | 1,401 (46.2) | 303 (42.5) | Â |
Full time ICU research staff, N (%) | ||||
< 1 FTE | 286 (7.6) | 280 (9.2) | 6 (0.8) | < 0.001 |
1 FTE | 740 (19.8) | 622 (20.5) | 118 (16.5) | Â |
> 1 FTE | 2,720 (72.6) | 2,131 (70.3) | 589 (82.6) | Â |
Formal trials group affiliation, N (%) | ||||
Yes | 3,224 (86.1) | 2,533 (83.5) | 691 (96.9) | < 0.001 |
No | 522 (13.9) | 500 (16.5) | 22 (3.1) | Â |
Country, N (%) | ||||
Canada | 2,456 (65.6) | 1,818 (59.9) | 638 (89.5) | < 0.001 |
Australia | 768 (20.5) | 715 (23.6) | 53 (7.4) | Â |
Brazil | 275 (7.3) | 272 (9.0) | 3 (0.4) | Â |
Saudi Arabia | 138 (3.7) | 135 (4.5) | 3 (0.4) | Â |
United States | 91 (2.4) | 77 (2.5) | 14 (2.0) | Â |
United Kingdom | 18 (0.5) | 16 (0.5) | 2 (0.3) | Â |
Characteristic of enrollment phase, N (%) | ||||
Pilot trial | 128 (3.4) | 126 (4.2) | 2 (0.3) | < 0.001 |
Year 1 | 556 (14.8) | 504 (16.6) | 52 (7.3) | Â |
Year 2 | 826 (22.1) | 626 (20.6) | 200 (28.1) | Â |
Year 3 | 1,009 (26.9) | 761 (25.1) | 248 (34.8) | Â |
Year 4 | 1,227 (32.8) | 1,016 (33.5) | 211 (29.6) | Â |