Table 1 Characteristics of patients enrolled in the present study
All patients (n= 76) | Survivors (n= 56) | Nonsurvivors (n= 20) | P value | |
|---|---|---|---|---|
Age, years, mean (SD) | 55 (19) | 52 (19) | 62 (16) | 0.04 |
Sex, male, n | 52 | 40 | 12 | 0.345 |
Admission, n | ||||
Surgical | 27 | 20 | 7 | 0.954 |
Clinical | 49 | 36 | 13 | |
Origin, n | ||||
Ward | 34 | 22 | 12 | 0.181 |
Emergency room | 42 | 34 | 8 | |
Sepsis, during ICU stay, n | 39 | 23 | 16 | 0.003 |
APACHE II score, points, mean (SD) | 19 (8) | 18 (8) | 20 (8) | 0.319 |
SOFA admission, points, mean (SD) | 6.6 (4.0) | 6.0 (3.4) | 8.3 (4.7) | 0.03 |
Mechanical ventilation during ICU stay, n | 46 | 29 | 17 | 0.008 |
Sedation during ICU stay, n | 50 | 32 | 18 | 0.008 |
Vasopressor need during ICU stay, n | 31 | 21 | 10 | 0.329 |
BDNF D0 mean (SD) | 4,831 (3,366) | 6,861 (2,764) | 5,736 (2,951) | 0.129 |
BDNF D2, mean (SD) | 5,865 (2,661) | 6,741 (2,356) | 3,413 (1,813) | < 0.0001 |
% variation BDNF, n | ||||
Decrease | 19 | 8 | 11 | 0.001 |
No change/increase | 57 | 48 | 9 |