Effects of etomidate on complications related to intubation and on mortality in septic shock patients treated with hydrocortisone: a propensity score analysis

Table 2 Comparison of main variables obtained before intubation according to occurrence of a short-term life-threatening complication

	Univariate analysis			Multivariate analysis
	No life-threatening complications following intubation ( n = 65)	Life-threatening complications following intubation ( n = 37)	P value	Odds ratio (95% CI)	P value
SAPS II upon ICU admission	48 (37 to 59)	54 (44 to 70)	< 0.01	1.04 (0.99 to 1.08)	0.08
SOFA score upon ICU admission	8 (6 to 12)	8 (6 to 11)	0.75
Main variables obtained before intubation
Lactatemia (mmol/l)	2.6 (1.1 to 4.9)	2.2 (1.5 to 3.9)	0.89
Vasopressors use	19 (29)	2 (6)	< 0.01	0.11 (0.01 to 0.93)	0.04
Lowest systolic blood pressure recorded within 30 minutes before intubation (mmHg)	89 (80 to 120)	100 (90 to 122)	0.08	1.01 (0.99 to 1.03)	0.09
Drug used to facilitate intubation
Etomidate	35 (53)	25 (69)	0.18
Other	31 (47)	11 (31)	0.05	0.60 (0.18 to 2.03)	0.41
Myorelaxants	62 (95)	35 (97)	0.86

Data presented as number (%) or median (quartiles). Multivariate analysis was performed using a logistic regression, which assesses the risk of life-threatening complication within the first hour after intubation. Each variable with P < 0.20 in the univariate analysis was entered in the model. Lowest systolic blood pressure before intubation, according to its median value, was forced into this model. CI, confidence interval; SAPS II, Simplified Acute Physiology Score II [35]; SOFA, Sequential Organ Failure Assessment [36].

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