Characteristic | All patients (n= 102) | Etomidate cohort (n= 60) | Non-etomidate cohort (n= 42) | P value |
---|---|---|---|---|
Age (years) | 69 (58 to 75) | 71 (62 to 72) | 68 (56 to 73) | 0.18 |
Male gender | 72 (71) | 44 (73) | 28 (67) | 0.002 |
Body mass index (kg/m2) | 25 (23 to 30) | 25 (23 to 29) | 26 (24 to 32) | 0.31 |
SAPS II upon ICU admission | 48 (40 to 63) | 52 (42 to 65) | 46 (34 to 58) | 0.049 |
SOFA score upon ICU admission | 8 (6 to 12) | 10 (7 to 13) | 8 (6 to 11) | 0.04 |
Previous disease | Â | Â | Â | Â |
   Hypertension | 43 (42) | 26 (43) | 17 (41) | 0.77 |
   Coronary artery disease | 22 (22) | 14 (23) | 8 (19) | 0.04 |
   Congestive heart failure | 29 (28) | 17 (27) | 12 (29) | 0.98 |
   Neurological disease | 20 (20) | 11 (18) | 9 (21) | 0.70 |
   Chronic obstructive pulmonary disease | 18 (18) | 10 (17) | 8 (19) | 0.76 |
   Diabetes mellitus | 20 (20) | 10 (17) | 10 (24) | 0.37 |
   Cancer | 41 (40) | 26 (43) | 15 (36) | 0.44 |
   Liver cirrhosis | 22 (21) | 14 (23) | 8 (19) | 0.61 |
Admitting diagnosis group | Â | Â | Â | Â |
   Medical | 42 (41) | 27 (45) | 15 (36) | 0.35 |
   Emergency surgery | 45 (44) | 23 (38) | 22 (52) | 0.16 |
   Elective surgery | 15 (15) | 10 (17) | 5 (12) | 0.55 |
Time from infection diagnostic to surgery (hours) | 8 (4 to 24) | 8 (5 to 24) | 8 (4 to 24) | > 0.99 |
Source of sepsis | Â | Â | Â | Â |
   Pulmonary | 33 (32) | 21 (35) | 12 (29) | 0.49 |
   Abdominal | 54 (53) | 25 (42) | 29 (69) | 0.02 |
   Other | 15 (15) | 14 (23) | 1 (2) | 0.03 |
Appropriateness of initial antibiotic therapy | 68/89 (76) | 39/52 (75) | 29/37 (78) | 0.71 |
Main variables obtained before intubation | Â | Â | Â | Â |
   Systolic blood pressure < 90 mmHg | 22(39) | 15 (45) | 7 (29) | 0.31 |
   SpO2 below 80% | 6 (10) | 5 (15) | 1 (4) | 0.21 |
   Lactatemia (mmol/l) | 2.5 (1.1 to 4.7) | 2.5 (1.1 to 5.3) | 2.3 (1.4 to 4.1) | 0.80 |
   Vasopressors use | 21 (21) | 16 (27) | 5 (12) | 0.09 |
   Myorelaxant use to facilitate intubation | 97 (98) | 57 (95) | 40 (98) | 0.96 |