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Table 3 Comparisons of patients treated with DCCT or non-DCCT

From: Antibiotic prescription patterns in the empiric therapy of severe sepsis: combination of antimicrobials with different mechanisms of action reduces mortality

 

DCCT group

n= 388 (28.3%)

Non-DCCT group

n= 984 (71.7%)

P

General data

Sex (male)

247 (63.7%)

590 (60%)

0.219

Age (years)

60.88 ± 16.79

62.78 ± 15.96

0.057

APACHE II

21.35 ± 7.43

21.47 ± 7.58

0.790

Lactate (mM)

36.37 ± 26.99

35.22 ± 26.93

0.578

Diagnosis on admission

Medical

310 (79.9%)

583 (59.6%)

<0.001

Trauma

3 (0.8%)

22 (2.2%)

0.074

Emergency surgery

59 (15.2%)

323 (33%)

<0.001

Elective surgery

16 (4.1%)

50 (5.1%)

0.487

Type of infection

Abdominal

56 (14.4%)

334 (33.9%)

<0.001

Urologic

44 (11.3%)

138 (14%)

0.216

Meningitis

5 (1.3%)

45 (4.6%)

0.002

Skin and/or soft-tissue

6 (1.5%)

48 (4.9%)

0.003

Catheter

4 (1%)

20 (2%)

0.256

Others

31 (8%)

107 (10.9%)

0.134

More than one focus

13 (3.4%)

19 (1.9%)

0.162

Organ failure

Number of organ failures

2.98 ± 1.26

2.98 ± 1.25

0.955

Hemodynamic

319 (82.2%)

810 (82.3%)

0.999

Respiratory

289 (74.5%)

591 (60.1%)

<0.001

Renal

264 (68%)

742 (75.4%)

0.007

Hepatic

61 (15.7%)

177 (18%)

0.343

Hematologic

94 (24.2%)

250 (25.4%)

0.679

Coagulation

131 (33.8%)

371 (37.7%)

0.191

Mortality

132 (34%)

394 (40%)

0.042