Patterns and early evolution of organ failure in the intensive care unit and their relation to outcome

Table 4 ICU and hospital mortality rates according to the number and type of failed organs and the presence of sepsis

	ICU mortality (%)			Hospital mortality
	No sepsis n = 1,789	Sepsis within 48 hours n = 865	Sepsis after 48 hours n = 279	No sepsis n = 1,789	Sepsis within 48 hours n = 865	Sepsis after 48 hours n = 279
On admission to the ICU
Any organ failure	20	30^a	30^a	25	40^a	37^a
1	13	20^a	30^a	18	30^a	36^a
2	25	30	29	33	41^a	38^a
3	44	48	32	47	56	36
> 3	55	60	50	64	73	50
Type of organ failure
Respiratory	10	34^a	31^a	25	44^a	36^a
CNS	34	32	27^a	38	42^b	36^a
Cardiovascular	25	38^a	28^b	31	48^a	33^a
Renal	20	32^a	31^a	26	44^a	42^a
Coagulation	22	46^a	33^b	27	58^a	50^b
Hepatic	20	34^a	64^a	28	42^a	64^a
At any time during the ICU stay
Any organ failure	17	28^a	30^a	22	38^a	37^a
1	5	6	7	9	16^a	13^a
2	24	23	27	32	34	34
3	47	43	42	50	52	51
>3	76	71	69	76	89	77
Type of organ failure
Renal	20	38^a	41^a	26	50^a	50^a
Respiratory	24	32^a	32^a	28	41^a	40^a
Cardiovascular	29	40^a	37^a	33	49^a	42^a
CNS	36	40^a	39^a	40	50^a	46^a
Coagulation	33	49^a	53^a	41	60^a	64^a
Hepatic	27	42^a	47^a	33	49^a	50^a

CNS, central nervous system; IQ, interquartile range. ^bP < 0.05; ^aP < 0.01 compared with patients without sepsis (pairwise comparisons with Bonferroni correction for multiple comparisons).

ISSN: 1364-8535