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Table 4 Sensitivity analyses for prediction of acute kidney injury excluding patients with author-defined reduced kidney function on entry

From: Clinical review: Predictive value of neutrophil gelatinase-associated lipocalin for acute kidney injury in intensive care patients

Study Patients excluded Number of patients included in analysis AuROC sensitivity analysis AuROC primary analysis
de Geus et al. [21] (plasma) eGFR <60 mL/minute/1.73 m2 at admission 498, of whom 7% (37) developed AKI AKI within 7 days 0.75 ± 0.10 AKI within 7 days 0.77 ± 0.05
de Geus et al. [21] (urine) eGFR <60 mL/minute/1.73 m2 at admission 498, of whom 7% (37) developed AKI AKI within 7 days 0.79 ± 0.10 AKI within 7 days 0.80 ± 0.04
Doi et al. [24] (urine) AKI at admission 274, of whom 24% (66) developed AKI AKI within 7 days 0.60 (0.52-0.67) AKI within 7 days 0.70 (0.63-0.75)
Constantin et al. [26] (plasma) AKI at admission 56, of whom 36% (20) developed AKI AKI within 7 days 0.96 (0.86-0.99) AKI within 7 days 0.92 (0.85-0.97)
Siew et al. [29] (urine) eGFR <75 mL/minute/1.73 m2 at admission 275, of whom 7% (18) developed AKI AKI within 24 hours 0.77 (0.64-0.90) AKI within 24 hours 0.71 (0.63-0.78)
Cruz et al. [25] (plasma) Only patients without AKI at enrollment were included in primary analyses.
Makris et al. [30] (urine) Only patients with sCr <1.5 mg/dL (133 μmol/L) on entry were included in primary analysis.
Endre et al. [22] (urine) Only patients without AKI on entry were included in primary analysis.
Metzger et al. [28] (urine) Only patients without AKI within 48 hours of admission were included in primary analysis.
Mårtensson et al. [27] (plasma) Only patients with eGFR >60 mL/minute/1.73 m2 on entry were included in primary analysis.
Mårtensson et al. [27] (urine) Only patients with eGFR >60 mL/minute/1.73 m2 on entry were included in primary analysis.
Kokkoris et al. [31] (plasma) Only patients with known baseline sCr <1.6 mg/dL (141 μmol/L) were included in primary analysis.
  1. Area under receiver operating characteristic curve (AuROC) presented as ± 2 × standard error or (95% confidence interval). AKI, acute kidney injury; eGFR, estimated glomerular filtration rate; sCR, serum creatinine.