Skip to main content

Table 3 Neutrophil gelatinase-associated lipocalin and prediction of study outcome measures

From: Clinical review: Predictive value of neutrophil gelatinase-associated lipocalin for acute kidney injury in intensive care patients

Study AKI events, percentage (number) 12 hours 24 hours AuROC 48 hours 72 hours 5 days 7 days RRT events, percentage (number) RRT AuROC Mortality events, percentage (number) Mortality AuROC NGAL cutoff value for AKI Sensitivity Specificity PPV NPV
de Geus et al. [21] (plasma) 27% (171) - - - - - 0.77 ± 0.05 4% (28) 0.88 ± 0.06 Hospital 22% (137) 0.63 ± 0.06 - - - - -
de Geus [12]et al. (urine) 27% (171) - - - - - 0.80 ± 0.04 4% (28) 0.89 ± 0.04 Hospital 22% (137) 0.64 ± 0.06 - - - - -
Endre et al.a [22] (urine) 22% (82) - - 0.55(0.48-0.67) - - 0.68(0.56-0.80) 4% (19) 0.79(0.65-0.94) 7 days 10% (53) 0.66(0.57-0.74) - - - - -
Doi et al. [24] (urine) 39% (131) - - - - - 0.70(0.63-0.75) - - 14 days 4% (14) 0.83(0.69-0.91) - - - - -
Cruz et al.b [25] (plasma) 14% (43) - - 0.78(0.65-0.90) - 0.67(0.55-0.79) - 5% (15) 0.82(0.70-0.95) in ICU 17% (52) 0.67(0.58-0.77) 150 ng/mL 48 hours 0.73 0.81 0.24 0.97
             5 days 0.46 0.80 0.26 0.91
Constantin et al. [26] (plasma) 59% (52) - - - - - 0.92(0.85-0.97) 8% (7) 0.79(0.69-0.87) in ICU 19% (17) - 155 ng/mL 0.83 0.97 0.97 0.80
Mårtensson et al. [27] (plasma) 72% (18) 0.67(0.39-0.94) - - - - - 4% (1) - 30 days 24% (6) - 120 ng/mL 0.83 0.50 - -
Mårtensson et al. [27] (urine) 72% (18) 0.86(0.68-1.0) - - - - - 4% (1) - 30 days 24% (6) - 68 ng/mgCr 0.71 1.0 - -
Metzger et al. [28] (urine) 45% (9) - - 0.54c - - - 20% (4) - - - - - - - -
Siew et al. [29] (urine) 19% (86) - 0.71(0.63-0.78) 0.64(0.57-71) - - - 3% (17) - 28 days 17% (83) - - - - - -
Makris et al. [30] (urine) 35% (11) - - - - 0.98(0.82-0.98) - - - in ICU 23% (7) - 25 ng/mL 0.91 0.95 - -
Kokkoris et al. [31] (plasma) 26% (24) - - - 0.78 - - 8% (7) - in ICU 33% (30) - 110 ng/mL 0.71 0.82 - -
Linko et al. d (plasma) - - - - - - - 13% (47) 0.73(0.66-0.81) 90 days 30% (111) 0.58(0.52-0.65) - - - - -
  1. Area under receiver operating characteristic curve (AuROC): (95% confidence interval) or ± 2 × standard error. aOf 528 included patients, 147 had acute kidney injury (AKI) on entry and were not included in primary analysis of AKI but were included in analysis of renal replacement therapy (RRT) and mortality. Study reported AuROC at 48 hours with Acute Kidney Injury Network (AKIN) criteria, whereas AuROC at 7 days was with RIFLE criteria sustained for a minimum of 24 hours; bof 301 included patients, 90 had AKI on entry and were not included in calculation of AuROC values; cauthor reported AuROC based on sample 2 to 3 days prior to AKI. dstudy unpublished. ADQI, Acute Dialysis Quality Initiative; GFR, glomerular filtration rate; ICU, intensive care unit; lcn2, lipocalin-2; MDRD, Modification of Diet in Renal Disease; NGAL, neutrophil gelatinase-associated lipocalin; RIFLE, Risk, Injury, Failure, Loss, and End-stage kidney disease; NPV, negative predictive value; PPV, positive predictive value; sCr, serum creatinine.