Study | AKI events, percentage (number) | 12 hours | 24 hours | AuROC 48 hours | 72 hours | 5 days | 7 days | RRT events, percentage (number) | RRT AuROC | Mortality events, percentage (number) | Mortality AuROC | NGAL cutoff value for AKI | Sensitivity | Specificity | PPV | NPV |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
de Geus et al. [21] (plasma) | 27% (171) | - | - | - | - | - | 0.77 ± 0.05 | 4% (28) | 0.88 ± 0.06 | Hospital 22% (137) | 0.63 ± 0.06 | - | - | - | - | - |
de Geus [12]et al. (urine) | 27% (171) | - | - | - | - | - | 0.80 ± 0.04 | 4% (28) | 0.89 ± 0.04 | Hospital 22% (137) | 0.64 ± 0.06 | - | - | - | - | - |
Endre et al.a [22] (urine) | 22% (82) | - | - | 0.55(0.48-0.67) | - | - | 0.68(0.56-0.80) | 4% (19) | 0.79(0.65-0.94) | 7 days 10% (53) | 0.66(0.57-0.74) | - | - | - | - | - |
Doi et al. [24] (urine) | 39% (131) | - | - | - | - | - | 0.70(0.63-0.75) | - | - | 14 days 4% (14) | 0.83(0.69-0.91) | - | - | - | - | - |
Cruz et al.b [25] (plasma) | 14% (43) | - | - | 0.78(0.65-0.90) | - | 0.67(0.55-0.79) | - | 5% (15) | 0.82(0.70-0.95) | in ICU 17% (52) | 0.67(0.58-0.77) | 150 ng/mL 48 hours | 0.73 | 0.81 | 0.24 | 0.97 |
 |  |  |  |  |  |  |  |  |  |  |  | 5 days | 0.46 | 0.80 | 0.26 | 0.91 |
Constantin et al. [26] (plasma) | 59% (52) | - | - | - | - | - | 0.92(0.85-0.97) | 8% (7) | 0.79(0.69-0.87) | in ICU 19% (17) | - | 155 ng/mL | 0.83 | 0.97 | 0.97 | 0.80 |
MÃ¥rtensson et al. [27] (plasma) | 72% (18) | 0.67(0.39-0.94) | - | - | - | - | - | 4% (1) | - | 30 days 24% (6) | - | 120 ng/mL | 0.83 | 0.50 | - | - |
MÃ¥rtensson et al. [27] (urine) | 72% (18) | 0.86(0.68-1.0) | - | - | - | - | - | 4% (1) | - | 30 days 24% (6) | - | 68 ng/mgCr | 0.71 | 1.0 | - | - |
Metzger et al. [28] (urine) | 45% (9) | - | - | 0.54c | - | - | - | 20% (4) | - | - | - | - | - | - | - | - |
Siew et al. [29] (urine) | 19% (86) | - | 0.71(0.63-0.78) | 0.64(0.57-71) | - | - | - | 3% (17) | - | 28 days 17% (83) | - | - | - | - | - | - |
Makris et al. [30] (urine) | 35% (11) | - | - | - | - | 0.98(0.82-0.98) | - | - | - | in ICU 23% (7) | - | 25 ng/mL | 0.91 | 0.95 | - | - |
Kokkoris et al. [31] (plasma) | 26% (24) | - | - | - | 0.78 | - | - | 8% (7) | - | in ICU 33% (30) | - | 110 ng/mL | 0.71 | 0.82 | - | - |
Linko et al. d (plasma) | - | - | - | - | - | - | - | 13% (47) | 0.73(0.66-0.81) | 90 days 30% (111) | 0.58(0.52-0.65) | - | - | - | - | - |