Outcome of ICU patients with Clostridium difficile infection

Table 4 Multivariate analysis to estimate independent prognostic effect of ICU-acquired CDI in the tested diarrheic patients (n = 490)

Parameter	CSHR_Death (95% CI) P	CSHR_Discharge (95% CI) P
Fixed variables at admission
CVA diagnosis at admission	3.94 (1.55 to 10.0) P = 0.004	1.19 (0.61 to 2.32) P = 0.6
Cardiac chronic disease (Knaus)	1.78 (1.09 to 2.9) P = 0.02	0.96 (0.67 to 1.38) P = 0.8
AIDS	2.91 (0.88 to 9.67) P = 0.08	0.87 (0.35 to 2.13) P = 0.8
Corticosteroid use	1.78 (0.87 to 3.65) P = 0.11	0.67 (0.41 to 1.10) P = 0.12
Death expected (McCabe)	1.76 (1.2 to 2.59) P = 0.004	1.04 (0.84 to 1.30) P = 0.7
Fixed variables in the first 48 hours
DNR Order	3.01 (1.74 to 5.22) P < .0001	0.77 (0.47 to 1.27) P = 0.3
Variable the days before test
SOFA the days before CD test	1.15 (1.09 to 1.22) P < .0001	0.90 (0.87 to 0.93) P < .0001
Variable on the day of the test
CDI	0.81 (0.40 to 1.64) P = 0.6	0.70 (0.5 to 1.01) P = 0.06

AIDS, Acquired Immune Deficiency Syndrome; BSI, Blood Stream Infection; CDI, Clostridium difficile infection; CRBSI, Catheter Related Blood Stream Infection; DNR, Do Not Resuscitate; CSHR (95%CI), Cause Specific Hazard ratio and 95% confidence interval; CVA, Cerebrovascular accident; SAPS, Simplified Acute Physiological Score; SOFA, Sequential Organ Failure Assessment. Other variables that were tested but not retained in the model were the following: at admission, age, sex, category of admission, symptom of septic shock, symptom of acute respiratory failure, hepatic chronic disease, pulmonary chronic disease, renal chronic disease, immunosuppressive chronic disease, diabetes mellitus, presence of at least one chronic disease, AIDS, and corticosteroid use; in the first 48 hours - vasopressors, central catheter, urinary tract, mechanical ventilation, Proton Pump Inhibitor, SOFA and SAPS II. See Additional file 1 for details on univariate analysis.

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