Table 7 Progression to septic shock (SS) and mortality after septic shock among patients with sepsis

+2960INDEL

With sepsis

363 (74.4)

153 (72.9)

-

-

Progression to SS

266/363 (73.3)

98/153 (64.1)

0.046

0.414

ICU mortality

135/266 (50.8)

51/98 (52.0)

0.920

-

ICU + hospital mortality

162/266 (60.9)

65/98 (66.3)

0.409

-

Polymorphism

Outcome

With +3003C, n (%)

Without +3003C, n (%)

P -value

+3003C>T

With sepsis

98 (20.9)

371 (79.1)

-

Progression to SS

71/98 (72.4)

258/371 (69.5)

0.663

-

ICU mortality

44/71 (62.0)

126/258 (48.8)

0.068

-

ICU + hospital mortality

50/71 (70.4)

160/258 (62.3)

0.244

-

Polymorphism

Outcome

With +3010C, n (%)

Without +3010C, n (%)

P -value

+3010C>G

With sepsis

373 (79.5)

96 (20.5)

-

-

Progression to SS

267/373 (71.6)

62/96 (64.6)

0.226

-

ICU mortality

135/267 (50.6)

35/62 (56.5)

0.487

-

ICU + hospital mortality

166/267 (62.2)

44/62 (71.0)

0.249

-

Polymorphism

Outcome

With +3027A, n (%)

Without +3027A, n (%)

P -value

+3027 A>C

With sepsis

36 (7.7)

433 (92.3)

-

-

Progression to SS

25/36 (69.4)

304/433 (70.0)

1.000

-

ICU mortality

15/25 (60.0)

155/304 (51.0)

0.510

-

ICU + hospital mortality

17/25 (68.0)

193/304 (63.5)

0.814

-

Polymorphism

Outcome

With +3035T, n (%)

Without +3035T, n (%)

P -value

+3035C>T

With sepsis

125 (26.7)

344 (73.3)

-

-

Progression to SS

96/125 (76.8)

233/344 (67.7)

0.075

-

ICU mortality

51/96 (53.1)

119/233 (51.1)

0.828

-

ICU + hospital mortality

63/96 (65.6)

147/233 (63.1)

0.757

-

Polymorphism

Outcome

With +3142G, n (%)

Without +3142G, n (%)

P -value

+3142C>G

With sepsis

431 (83.5)

85 (16.5)

-

-

Progression to SS

309/431 (71.7)

55/85 (64.7)

0.245

-

ICU mortality

157/309 (50.8)

29/55 (52.7)

0.908

-

ICU + hospital mortality

188/309 (60.8)

39/55 (70.9)

0.204

-

Polymorphism

Outcome

With +3187ª, n (%)

Without +3187ª, n (%)

P -value

+3187A>G

With sepsis

447 (95.3)

22 (4.7)

-

-

Progression to SS

316/447 (70.7)

13/22 (59.1)

0.356

-

ICU mortality

162/316 (51.3)

8/13 (61.5)

0.658

-

ICU + hospital mortality

200/316 (63.3)

10/13 (76.9)

0.479

-