Table 1 Clinical characteristics of patients in the fluoroquinolone and nonfluoroquinolone groups on ICU admission
| Â | Fluoroquinolone (n= 43) | Nonfluoroquinolone (n= 34) | P value |
|---|---|---|---|
Age (years) | 72.9 ± 12.4 | 76.2 ± 14.5 | 0.28 |
Male | 33 (77) | 26 (77) | 0.99 |
Underlying diseases | 41 (95) | 33 (97) | >0.99 |
   Diabetes mellitus | 12 (28) | 6 (18) | 0.29 |
   COPD | 5 (12) | 9 (27) | 0.09 |
   Malignancy | 8 (19) | 5 (15) | 0.65 |
   Autoimmune disease | 2 (5) | 1 (3) | 0.7 |
   Liver cirrhosis | 2 (5) | 0 (0) |  |
   HIV | 0 (0) | 2 (6) |  |
Initial symptoms | Â | Â | Â |
   Respiratory symptoms | 40 (93) | 32 (94) | >0.99 |
   Fever | 27 (63) | 12 (35) | 0.02 |
   Consciousness disturbance | 11 (26) | 4 (12) | 0.13 |
APACHE score | 21.2 ± 7.1 | 22.5 ± 7.5 | 0.46 |
   Arterial pH | 7.4 ± 0.1 | 7.4 ± 0.1 | 0.19 |
   Serum sodium | 136.6 ± 6.7 | 135.0 ± 8.5 | 0.35 |
   Serum potassium | 3.9 ± 0.8 | 4.1 ± 0.7 | 0.26 |
   Serum creatinine | 1.8 ± 1.7 | 1.9 ± 1.8 | 0.87 |
   Hematocrit | 32.5 ± 6.8 | 32.6 ± 5.6 | 0.93 |
   Leukocyte count (103/μl) | 13.9 ± 8.5 | 12.8 ± 7.2 | 0.53 |
   FiO2 ³50% | 32 (74) | 20 (59) | 0.22 |
Albumin (g/dl) | 2.7 ± 0.5 | 2.8 ± 0.5 | 0.29 |
Bacteremia in ICUa | 5 (12) | 6 (18) | >0.99 |
SOFA score | 8.0 ± 3.6 | 7.3 ± 3.9 | 0.47 |
Radiographic findings | Â | Â | Â |
   Bilateral involvement | 34 (79) | 27 (79) | >0.99 |
   Cavitation | 3 (7) | 0 (0) | 0.25 |
   Miliary | 1 (2) | 1 (3) | >0.99 |
   Pleural effusion | 21 (49) | 21 (62) | 0.36 |
Smear-positive for acid-fast bacilli | 3 (7) | 5 (15) | 0.47 |
Steroid use | 21 (49) | 19 (56) | 0.65 |
Undergone bronchoscopy | 5 (12) | 5 (15) | 0.95 |