Table 1 Baseline characteristics
| Â | CVVH (n= 39) | CVVHD (n= 38) |
|---|---|---|
Age, years | 58.8 ± 13.7 | 64.3 ± 14.3 |
Female | 14 (36%) | 16 (42%) |
Weight, kg | 86.6 ± 31.5 | 89.2 ± 26.4 |
Days from ICU admission to randomization | 2 (1, 4) | 2 (1, 3) |
SOFA score | 16.3 ± 3.3 | 15.5 ± 3.0 |
Premorbid conditions | ||
Hypertension | 19 (49%) | 26 (68%) |
Diabetes mellitus | 9 (23%) | 9 (24%) |
Chronic kidney disease | 5 (13%) | 13 (34%) |
Acute kidney injury risk factors | ||
Sepsis | 31 (79%) | 32 (84%) |
Cardiopulmonary bypass in past 7 days | 1 (3%) | 4 (11%) |
IV contrast in past 7 days | 9 (23%) | 6 (16%) |
Physiologic parameters | ||
Urine output, mL/24 hr | 125 (60, 245) | 135 (46, 251) |
Minimum systolic BP during 24 hr before enrolment, mmHg | 94.2 ± 16.5 | 86.1 ± 13.5 |
Minimum diastolic BP during 24 hr before enrolment, mmHg | 48.9 ± 8.6 | 47.2 ± 9.4 |
Laboratory parameters | ||
Serum creatinine, µmol/L | 276 (194, 352) | 246 (155, 325) |
Urea, mmol/L | 25.8 ± 38.1 | 17.6 ± 12.7 |
Potassium, mmol/L | 4.3 ± 0.7 | 4.1 ± 0.6 |
Bicarbonate, mmol/L | 20.5 ± 5.9 | 20.2 ± 5.3 |
Hemoglobin, g/L | 86.1 ± 16.3 | 90.0 ± 15.2 |
Platelets, × 109/L | 109.6 ± 82.6 | 127.2 ± 80.9 |
WBC, × 109/L | 20.2 ± 43.3 | 16.9 ± 10.6 |
ICU interventions | ||
Duration of RRT prior to randomization, hours | 8 (0, 19) | 13 (1.0, 20.5) |
Mechanical ventilation | 37 (95%) | 36 (95%) |
Vasopressors | 34 (87%) | 35 (92%) |
Total parenteral nutrition | 1 (3%) | 2 (5%) |