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Box 1 Search strategies

From: Clinical review: Goal-directed therapy-what is the evidence in surgical patients? The effect on different risk groups

1. MEDLINE database (OVID interface): the Cochrane highlysensitive search strategy was used:

#1. randomized Controlled Trials as Topic/

#2. randomized controlled trial/

#3. random Allocation/

#4. double Blind Method/

#5. single Blind Method/

#6. clinical trial/

#7. controlled clinical trial.pt.

#8. randomized controlled trial.pt.

#9.multicenter study.pt.

#10.clinical trial.pt.

#11. expClinical Trials as topic/

#12. or/1-11

#13. (clinical adj trial$).tw.

#14. ((singl$ or doubl$ or treb$ ortripl$) adj (blind$3 or mask$3)).tw.

#15. randomly allocated.tw.

#16. (allocated adj2random$).tw.

#17. or/13-16

#18. 12 or 17

#19. casereport.tw.

#20. letter/

#21.historical article/

#22. or/19-21

#23. 18 not 22

#24. exp surgery/

#25. surgery.tw.

#26.surgery.mp.

#27. 24 or 25 or 26

#28. exp goal directed/or goaldirected.tw. or goal directed.mp.

#29. exp goal oriented/or goaloriented.tw. or goal oriented.mp.

#30 exp goal target/or goal target.tw. or goaltarget.mp.

#31. exp cardiac output/or cardiac output.tw. or cardiac output.mp.

#32. exp cardiac index/or cardiac index.tw. or cardiac index.mp.

#33. exp oxygen delivery/or oxygen delivery.tw. or oxygen delivery.mp.

#34. exp oxygen consumption/or oxygen consumption.tw. or oxygen

consumption.mp

#35. exp cardiac volume/or cardiac volume.tw. or cardiac volume.mp.

#36. exp stroke volume/or stroke volume.tw. or strokevolume.mp.

#37. exp fluid therapy/or fluid therapy.tw. or fluidtherapy.mp.

#38. exp fluid loading/or fluid loading.tw. or fluidloading.mp.

#39. exp fluid administration/or fluid administration.tw. orfluid administration.mp.

#40. exp optimization/or optimization.tw. or optimization.mp.

#41. exp optimisation/or optimisation.tw. oroptimisation.mp.

#42. expsupranormal/or supranormal.tw. orsupranormal.mp.

#43. exp lactate/orlactate.tw. or lactate.mp.

#44. expextraction ratio/or extraction ratio.tw. orextraction ratio.mp.

#45. #28 or #29or #30 or #31 or #32 or #33 or #34 or #35or #36 or #37 or #38 or #39 or #0or#41or #42 or #43 or #44

#46. #23and #27 and #45

2. Embase (OVIDinterface): search restricted to the years2009 to 2012:

#1. Clinicaltrial/

#2. Randomizedcontrolled trial/

#3.Randomization/

#4.Single blind procedure/

#5. Double blindprocedure/

#6. Crossoverprocedure/

#7. Placebo/

#8. Randomi?ed controlledtrial$.tw.

#9. Rct.tw.

#10. Random allocation.tw.

#11.Random allocated.tw

#12. Allocated randomly.tw.

#13.(allocated adj2 random).tw.

#14. Single blind$.tw.

#15.Double blind$.tw.

#16.Placebo$.tw

#17.Prospectie study/

#18. Or/1-17

#19. Casestudy/

#20. Case report.tw.

#21. Abstract report/or letter/

#22. Or/19-21

#23. 18 not22

#24. surgery

#25. expsurgery/or surgery

#26.surg$

#27. 24 or 25or 26

#28. exp heart/or heart.mp.)and output.mp.

#29. expheart output/or heart output.mp.

#30. goal directed

#31. goaloriented

#32. goal target

#33. exp heart index/or heartindex.mp.

#34. exp heart strokevolume/or heart stroke volume.mp.

#35. expoxygenconsumption/or oxygen consumption.mp.

#36. oxygendelivery.mp.

#37. exp fluidtherapy/

#38. fluidadministration.mp

#39. fluidloading.mp.

#40. hemodynamic.mp

#41. supranormal.mp.

#42.optimisation.mp.

#43. optimization.mp.

#44. exp lactate/

#45. extraction ratio.mp

#46. #28 or #29 or #30 or #31 or #32 or #33 or #34 or #35 or #36 or #37 or #38 or #39 or #40 or #41 or #42 or #43 or #44 or #45

#47. #23 and #27 and #46

3. Cochrane clinical trials database (CENTRAL):

#1. surgery in Trials

#2. surgical* in Trials

#3. surgery* in Trials

#4. #1 OR #2 OR #3

#5. cardiac near output* in trials

#6. cardiac near volume* in Trials

#7. cardiac near index* in Trials

#8. oxygen near delivery* in Trials

#9. oxygen near consumption* in Trials

#10. supranormal* in Trials

#11. stroke near volume* in Trials

#12. fluid near therapy* in Trials

#13. fluid near administration* in Trials

#14. fluid near loading* in Trials

#15. extraction near ratio* in Trials

#16. lactate* in Trials

#17. goal near directed* in Trials *

#18. goal near oriented* in Trials

#19. goal near target* in Trials

#20. Hemodynamic near optimization* in trials

#21. Haemodynamic near optimization * in trials

#22. Optimization* in trials

#23. Optimisation* in trials

#24. #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23

#25. #4 AND#24